Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: genetic + premenstrual + depression  Related to the article below (Last Update: 8/5/2008)

Helicos Announces Order for a Helicos Genetic Analysis System from ...
MarketWatch - 27 minutes ago
today announced that a leading US cancer research center has placed an order for a Helicos(TM) Genetic Analysis System for use in a cutting-edge research ...
Helicos and Uppsala University Collaborate to Study Genome ... MarketWatch
all 6 news articles »
Genetic Evidence Used To Trace Ancient African Migration
Science Daily (press release) -
Using a genetic technique pioneered at Stanford, the team found that animal-herding methods arrived in southern Africa 2000 years ago on a wave of human ...

Times Colonist
Genetic discovery may lead to blood test for families with high ...
The Canadian Press, TORONTO -
TORONTO ? Canadian researchers have uncovered a genetic anomaly in people with a higher-than-normal risk of developing cancer that could lead to a blood ...
Genetic discovery offers hope to family with legacy of cancer Canada.com
Genetic discovery may lead to new blood test for people at high ... Canada NewsWire (press release)
HOSPITAL FOR SICK CHILDREN Canada NewsWire (press release)
all 55 news articles »
DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal
PR Web (press release), WA -
The rapid growth in popularity of DNA testing and genetic profiling is proving many skeptics wrong. A recent poll shows that the benefits available from ...

Oneindia
Irish teams play key role in genetic finding
Irish Times, Ireland -
IRISH RESEARCHERS have played a key role in a new discovery about the genetics of schizophrenia. The finding, that rare structural changes in a person's DNA ...
Genetic Factors Behind Schizophrenia Identified Oneindia
all 2 news articles »
GeneLink Announces Launch of Genetically-customized Nutrition and ...
MarketWatch -
Utilizing GeneLink's patented and patent pending genetic profiles, customers of GeneWize will be able complete a simple, non-invasive GeneLink Healthy Aging ...OTC:GNLK
SFI funded Researchers Contribute to Important Genetic Findings in ...
Science Foundation Ireland, Ireland -
The separate reports, published in the journal Nature Genetics, identify specific risk genes. In bipolar disorder, the identified genes are known to be ...
Genetic testing brings new hopes, hard choices
Boston Globe, United States - Aug 3, 2008
But that genetic knowledge helped to persuade him, though he was in excellent health, to opt for a major intervention: a defibrillator implanted in his ...
Genetic mutation may heighten HIV risk
Louisville Courier-Journal, KY - Aug 4, 2008
A genetic mutation that originally protected Africans from a virulent form of malaria now renders them 40 percent more susceptible to HIV infections, ...

BBC News
Increased Burden Of Rare Genetic Variations Found In Schizophrenia
Science Daily (press release) - Jul 31, 2008
ScienceDaily (July 30, 2008) ? People with schizophrenia bear an "increased burden" of rare deletions and duplications of genetic material, genome-wide, ...
Genetic hot spots tied to schizophrenia Boston Globe
Genetic clue to schizophrenia found Xinhua
Schizophrenia studies back genetic theory ABC Online
Washington Post - HealthNews
all 433 news articles »
Source: Google News

… -Based Twin Study of Retrospectively Reported Premenstrual Symptoms and Lifetime Major Depression -
KS Kendler, LM Karkowski, LA Corey, MC Neale - American Journal of Psychiatry, 1998 - Am Psychiatric Assoc
... The genetic and environmental risk factors for these premenstrual symptoms
and lifetime major depression are not closely related. ...

Hormones and depression: what are the facts about premenstrual syndrome, menopause, and hormone … -
TB Pearlstein - Am J Obstet Gynecol, 1995 - pt.wkhealth.com
... Genetic and environmental factors in the aetiology of menstrual ... Altered waveform
of plasma nocturnal melatonin secretion in premenstrual depression. ...

Genetic and environmental factors in the aetiology of menstrual, premenstrual and neurotic symptoms: … -
KS Kendler, JL Silberg, MC Neale, RC Kessler, AC … - Psychol Med, 1992 - ncbi.nlm.nih.gov
... symptoms (ie anxiety, depression and somatization). Familial resemblance for menstrual
and premenstrual symptoms was due solely to genetic factors with ...

Genetic risk factors for major depression in men and women: similar or different heritabilities and … -
KS KENDLER, CO GARDNER, MC NEALE, CA PRESCOTT - Psychological Medicine, 2001 - pt.wkhealth.com
... A population-based twin study of major depression in women ... Genetic and environmental
factors in the aetiology of menstrual, premenstrual and neurotic ...

A Population-Based Twin Study of Lifetime Major Depression in Men and Women -
KS Kendler, CA Prescott - Archives of General Psychiatry, 1999 - archpsyc.highwire.org
... 3. Model Fitting for Lifetime Major Depression in Male ... this hypothesis, we recently
found that genetic risk factors for premenstrual symptoms accounted ...
-

… and environmental factors in premenstrual symptom reporting and its relationship to depression and … -
OB van den Akker, FF Eves, GS Stein, RM Murray - J Psychosom Res, 1995 - ncbi.nlm.nih.gov
... There was no evidence for a specific genetic contribution of depression or premenstrual
symptom reporting over and above those shown in the common personality ...

Genetic and environmental influences on premenstrual symptoms in an Australian twin sample. -
SA TRELOAR, AC HEATH, NG MARTIN - Psychological Medicine, 2002 - pt.wkhealth.com
... of Virginia twin sample data, which showed that genetic and environmental risk factors
for premenstrual symptoms and lifetime major depression were not closely ...

-
K Dalton - Hamline L. Rev., 1986 - HeinOnline
... Weight, racial, genetic, dietetic, social, and economic factors influence the onset ...
and temporary psychosis.2 A. Depression Premenstrual depression is different ...

The etiology, biology, and evolving pathology of premenstrual syndromes -
U Halbreich - Psychoneuroendocrinology, 2003 - Elsevier
... The incidence of depression among PMS patients ... of similar symptoms which are not
premenstrual. ... an additional pathobiological component: Genetics and dynamically ...

… Chronic Fatigue Syndrome, Migraine, Irritable Bowel Syndrome, Atypical Facial Pain, and Premenstrual … -
AJ Gruber, JI Hudson, HG Pope - Psychiatric Clinics of North America, 1996 - Elsevier
... irritable bowel syndrome, atypical facial pain, and premenstrual dysphoric disorder. ...
suggesting an association between these disorders and depression; and (3 ...

Source: Google Scholar

Genetic Link To Premenstrual Depression
A specific genetic variation may be tied to an increased risk for severe premenstrual depression, scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health have found.

Known medically as premenstrual dysphoric disorder, or PMDD, this psychiatric condition affects roughly 8 percent of women in their childbearing years. It's characterized by bouts of major depression and/or anxiety and severe irritability during the second half of the menstrual cycle. Symptoms subside with the onset of each menstrual period.
While PMDD has been thought to be linked to hormonal changes over the course of the menstrual cycle, until now an explanation for the susceptibility to hormone-related mood changes has been elusive. "Our initial hope in the study was that by looking at steroid-related genes like those for receptors for steroid hormones such as estrogen, we would be able to find gene differences that might explain why some women have these mood disorders and others don't," said Dr. David R. Rubinow, the study's senior author and the Meymandi distinguished professor and chair of psychiatry at UNC School of Medicine. "This study may begin to provide important clues to the nature of that susceptibility."

The study is the first to identify a genetic variation linked to a mood disorder associated with endocrine changes during the menstrual cycle, Rubinow said. The results will appear in an upcoming print edition of the journal Biological Psychiatry and were published online June 30, 2007. The study was supported by funds from the Intramural Research Program at the National Institute of Mental Health (NIMH).

The research involved 91 women for whom the authors prospectively confirmed a diagnosis of PMDD over at least three months. Another 56 women who had no history of mood disorders related to the menstrual cycle served as a comparison group. All the women provided blood samples for genetic analysis.

The team discovered four specific genetic variants, called single nucleotide polymorphisms, in one of the two genes that encode the estrogen receptor. The variants, which are differences in strings of DNA nucleotides A, G, C, or T, were identified in the estrogen receptor alpha gene, ESR1.

Compared to the control group, women with PMDD were significantly more likely to have the ESR1 gene variants, the study found.

"While these are preliminary findings that require replication in larger studies, we would argue that this may explain part of the variance among women in the susceptibility to developing this mood disorder," Rubinow said. "Studies have shown that PMDD is characterized by abnormal sensitivity to reproductive steroids like estrogen. As a receptor for the hormone that can trigger the onset of PMDD symptoms, ESR1 has clear physiologic relevance for this disorder."
The authors acknowledge that as with other complex genetic disorders, the contribution to PMDD of polymorphisms in a single gene may not be large. In addition, they also noted that the findings may be telling us more about the control group.

These women, who have no history of psychiatric problems or menstrual cycle-related symptoms, may have gene variants that protect against PMDD. According to Rubinow, "this is equally interesting because it may help us to understand resilience and protection, which are also very important."

Dr. Susan S. Girdler, professor of psychiatry and director of the UNC Psychiatry Stress and Health Research Program, pointed out that the severity of PMDD symptoms are as great or can be as great as those of women with full-blown major depression or major anxiety disorder. "But what makes them different is that the symptoms are very time-limited and linked strongly with the women's menstrual cycle."

Girdler emphasizes that to qualify for PMDD, symptoms must be severe enough to interfere with everyday functioning - to disrupt relationships, result in social withdrawal, even prompt thoughts of suicide. "We are talking about women who meet very stringent diagnostic criteria for PMDD. This is not the garden variety PMS."

Rubinow's coauthors were from the National Institute of Mental Health's Behavioral Endocrinology Branch and Program on Genes, Cognition and Psychosis.

The UNC Center for Women's Mood Disorders is conducting follow-up studies on the genetic and environmental contributors to PMDD. Eligible women will receive free diagnostic and medical evaluations, and may be eligible to take part in reatment studies or studies providing monetary compensation.

Source: Les Lang
University of North Carolina School of Medicine
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.