Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: immune + system + cancer  Related to the article below (Last Update: 8/5/2008)

Immunotherapy Boosts Treatment of Kids' High-Risk Sarcomas
Washington Post, United States -
The study involved a new dendritic vaccine as well as a standard flu vaccine to potentially strengthen the immune system following chemotherapy. ...
Boosting Hope For Cancer Sufferers
Voxy, New Zealand -
5 August 2008 - Development of a more effective treatment for cancer that involves teaching the immune system to hunt out and destroy tumours has been the ...

Pak Watan
Injected vitamin C cuts cancer growth
ABC Online, Australia -
In the latest study researchers injected the vitamin C to enable greater concentrations of it to get into the system. Injections were necessary because the ...
Vitamin C 'slows cancer growth' BBC News
High dose shot of vitamin C halts the spread of cancer News-Medical.net
all 93 news articles »
German Association of Gynecology and Obstetrics Recommends HPV ...
MarketWatch -
In most cases, the infection is cleared by the immune system or is suppressed without causing problems. However, in others, the infection persists, ...
Strengthen your immune system to fight cancer and other diseases
DailyNewsOnline, United Republic of Tanzania - Jul 27, 2008
Cancer cells occur between 6 to more than 10 times in a person?s lifetime. When the person?s immune system is strong, the cancer cells will be destroyed and ...
Idera Pharmaceuticals Reports Second Quarter 2008 Financial Results
MarketWatch - Aug 4, 2008
Our proprietary drug candidates are designed to modulate specific Toll-like Receptors, which are a family of immune system receptors that direct immune ...IDRA - PINK:RCRS

Malaysia Star
Have fewer sick days!
Malaysia Star, Malaysia - Aug 2, 2008
What parents don?t know is that a lot of these illnesses can be triggered by immune system problems and certain lifestyle practices. ...
New Research Results Explain How Dormant Tumor Cells Become Active ...
National Institutes of Health (press release) - Aug 1, 2008
The results of this study by National Cancer Institute (NCI) scientists and their collaborators, appears in the August 1, 2008, issue of Cancer Research. ...
Immunotherapy In High-risk Pediatric Sarcomas Shows Promising Response
Science Daily (press release) - Aug 1, 2008
The dendritic vaccine included peptides derived from each patient's individual cancer in a way that was designed to alert a patient's immune system to the ...
Newly Discovered Gene Variant Implicated In Lupus - Cutting The ...
Medical News Today (press release), UK - Aug 4, 2008
Your immune system may have more in common with a Corvette than you thought. When a virus or bacteria enters a human body, the immune system revs up to ...
Source: Google News

Is cancer dangerous to the immune system? -
EJ Fuchs, P Matzinger - Seminars in Immunology, 1996 - Elsevier
Page 1. Is cancer dangerous to the immune system? EphraimJ.Fuchs* and
PollyMatzinger? The hypothesis of immunologic surveillance ...

Paradoxical roles of the immune system during cancer development -
KE de Visser, A Eichten, LM Coussens? - Nat Rev Cancer, 2006 - palgrave-journals.com
... Paradoxical roles of the immune system during cancer development. Karin E. de Visser
1 , Alexandra Eichten 2 and Lisa M. Coussens 2, 3, 4 About the authors. ...

Effects of TGF-beta on the immune system: implications for cancer immunotherapy. -
KE de Visser, WM Kast - Leukemia, 1999 - ncbi.nlm.nih.gov
Leukemia. 1999 Aug;13(8):1188-99. Effects of TGF-beta on the immune system:
implications for cancer immunotherapy. de Visser KE, Kast WM. ...

[PDF] CD95's deadly mission in the immune system -
PH Krammer - Nature, 2000 - uwcvb.org
... Apoptosis in the immune system is a fundamental process ... and during the course of
an immune response. ... pathogenesis of diseases such as cancer, autoimmunity and ...
-

Stress, depression, the immune system, and cancer -
EMV Reiche, SOV Nunes, HK Morimoto - Lancet Oncology, 2004 - Elsevier
... 2004 Elsevier Ltd All rights reserved. Review. Stress, depression, the immune
system, and cancer. Edna Maria Vissoci Reiche a , Corresponding ...

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by … -
Y Iwai, M Ishida, Y Tanaka, T Okazaki, T Honjo, N … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... we examined possible roles of the PD-1/PD-L system in tumor ... for potentially immunogenic
tumors to escape from host immune responses and ... Home page, Cancer Res. ...

STRESS, OPIOID PEPTIDES, THE IMMUNE SYSTEM, AND CANCER^ -
Y SHAVIT, W LEWIS, JC LIEBESKIND, RP GALE - The Journal of Immunology - Am Assoc Immnol
... 30, or IMMUNE SYSTEM, AND CANCER 835s 50 mg/kg. Untreated rats served as controls. ...
Page 3. 836s STRESS, OPIOID PEPTIDES, THE IMMUNE SYSTEM, AND CANCER I W -1 ...

Endocannabinoids in the immune system and cancer -
D Parolaro, P Massi, T Rubino, E Monti - Prostaglandins, Leukotrienes & Essential Fatty Acids, 2002 - Elsevier
Page 1. Endocannabinoids in the immune system and cancer D.Parolaro, 1
P.Massi, 2 T.Rubino, 1 E.Monti 1 1 Department of Structuraland ...

Decoding the Patterns of Self and Nonself by the Innate Immune System -
R Medzhitov, CA Janeway - Science, 2002 - sciencemag.org
... Cancer Res 64: 7596-7603 [Abstract] [Full Text ... D-Glucan-dependent Prophenoloxidase
Activation System of Insect. ... the full range of host immune relationships with ...

Transfer of a functional human immune system to mice with severe combined immunodeficiency -
DE Mosier, RJ Gulizia, SM Baird, DB Wilson - Nature, 1988 - palgrave-journals.com
... cells into SCID mice may provide a useful model for the study of normal human immune
function, the response of the immune system to pathogenic ... Cancer Res. ...

Source: Google Scholar

Cancers Evade The Body's Immune System So Anticancer Vaccines Mostly Fail
Scientists at Johns Hopkins and elsewhere say they have mapped out an escape route that cancers use to evade the body's immune system, allowing the disease to spread unchecked.

In a report published in the July 1 issue of the journal Nature Medicine, the Hopkins team, along with researchers from Florida and Nebraska, describe how myeloid-derived suppressor cells (MDSCs), which normally keep the immune system in check and prevent it from attacking otherwise healthy tissue, can suppress the anti-tumor response to cancer.

These suppressor cells block other immune system cells, CD8 'killer' T cells, from binding with proteins that identify the foreign antigens on the surface of unhealthy cancer cells, marking them for destruction, the team reports.
The good news, they say, is that their experiments also suggest that the chain reactions in T-cell tolerance are reversible, raising the possibility of vaccine and drug therapies that break through the blocked immune system.

Previous research had confirmed that MDSCs, produced in the bone marrow, were attracted to tumors, but until now, scientists had not identified exactly how the cells inhibit the immune system's ability to mount an attack.

By explaining some of the precise biological workings of MDSCs in cancer the team's findings suggest why experimental cancer vaccines have to date been plagued by T-cell tolerance, a weakened rather than strengthened immune response, says Jonathan Schneck, M.D., Ph.D., one of the study's authors.

"Our findings also open up a new door in drug and vaccine development that we never knew existed and provide another opportunity for drug development into autoimmune diseases, where the immune system is in overdrive and needs to be slowed down," says Schneck, a professor of medicine, pathology and oncology at The Johns Hopkins University School of Medicine and its Kimmel Cancer Center.

The team's latest report built on research initially conducted at the University of South Florida, where researchers analyzed blood samples and lymph tissue from healthy mice injected with MDSCs and found that T-cell levels remained the same, indicating that MDSCs did not destroy the immune response but apparently altered how the T cells behaved.

Using chemical tests in which individual tumor cells can be tagged with a fluorescent dye that allows them to glow when they are not bound to T cells, Florida researchers measured the immune response in mice to various foreign proteins, with and without injections of MDSCs. They found an 80 percent suppression of the immune response in the presence of MDSCs, confirming that the suppressor cells were inactivating the T cells.

The Florida team then turned to Schneck, who in 1993 developed several novel proteins to test how various antigens, such as those on cancer cells, specifically latch on to T cells.

Researchers then began experiments to determine if the MDSC T-cell interference was simply genetic or had some biochemical explanation, testing a half-dozen major reactions known to occur during infection to see if any set path was particularly active during interference.

In tissue tests from tumor-filled mice bred to lack a biochemical reaction, the scientists found that one specific pathway, the reactive-oxygen species, or ROS pathway, stood out, because when inactivated, T-cell tolerance did not develop. Researchers were surprised when subsequent tests showed that ROS actually modified the T cells, altering their structure so they could no longer bind to tumor-cell antigens.
When a known byproduct of ROS, the chemical peroxynitriate, was neutralized, T-cell tolerance failed to develop in test tube studies, pinning down peroxynitrate as the culprit prohibiting immune cell binding to and marking of 'foreign' tumor cells.

"Peroxynitrate activity is the escape hatch, and now that we have identified it, we can try to cut it off before T-cell tolerance develops, or you can reverse it," says Schneck.

Plans are underway to investigate the binding receptors of MDCSs and different anticancer drugs for their ability to lower levels of MDSCs and to explore the role of MDSCs in suppressing the immune response to stress, bacterial and viral infections, organ transplantation and autoimmune diseases. Their goal, researchers say, is to find some means of accelerating or slowing down T-cell activity gone awry.

Study support was provided with funding from the National Institute of Allergy and Infectious Diseases, and the National Cancer Institute, both members of the National Institutes of Health.

Study co-authors include Kapil Gupta, Ph.D., from Hopkins; Srinavas Nagaraj, Loveleen Kang, Donna Herber and Dimitry I. Gabrilovich, Ph.D., from the H. Lee Moffitt Cancer Center at the University of South Florida; and Vladimir Pisarev, Leo Kinarsky and Simon Sherman from the University of Nebraska Medical Center and Eppley Cancer Center. Gabrilovich was the study senior author.

Source: David March
Johns Hopkins Medical Institutions
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.