Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: asthma + research + may  Related to the article below (Last Update: 8/5/2008)

Obese people may carry asthma trait
Newstrack India, India -
... are obese with asthma may carry a specific trait that causes them to have poorer asthma control than their slim counterparts, suggests a new research. ...
Asthma, Acid Reflux: What's the Connection?
FOXNews -
By Jessica Ryen Doyle When Debra Peterson tells her patients their worsening asthma symptoms may be related to gastroesophageal reflux disease, or GERD, ...
Air fresheners, cleaners may be bad for health
Chicago Tribune, United States -
A clean, fresh-smelling home may actually be bad for your health. Recent research suggests that exposure to cleaning products or air fresheners that contain ...
Idera Pharmaceuticals Reports Second Quarter 2008 Financial Results
MarketWatch - Aug 4, 2008
Asthma and Allergies: In collaboration with Novartis International Pharmaceutical, Ltd. In June 2005, the Company and Novartis announced they had entered ...IDRA - PINK:RCRS
Chest infections, not antibiotics make babies wheeze
SINDH TODAY, Pakistan - Aug 4, 2008
The study led by Julian Crane, director, Wellington Asthma Research Group, relied on approximately 1000 children from Wellington and Christchurch from birth ...
American Lung Association Offers Olympic Spectators Tips to Stay ...
MarketWatch -
For even the healthiest people, air pollution can irritate the respiratory tract and cause serious health problems such as asthma attacks, coughing and ...
Clinical Data Acquires Adenosine Therapeutics
Business Wire (press release), CA -
Novartis holds an option to partner on the development of ATL844, in preclinical study for the treatment of diabetes and asthma, and a confidential partner ...CLDA

NHS Choices
Flu jab and pneumonia
NHS Choices, UK -
When the researchers took into account all the factors they believed may have influenced the outcome including age, sex, asthma, smoking, antibiotics for ...
Be wary of Henna tattoos
Belleville News Democrat,  USA -
New research findings suggest that some children with food allergies may not be equipped with enough medication to reverse a severe allergic reaction. ...

TopNews
Frankincense May Ease Osteoarthritis Symptoms ? A Study
TopNews, India - Aug 2, 2008
During the research, scientists used AKBA from the plant for the extract. They discovered that osteoarthritis patients, who were on the drug got relief ...
Source: Google News

The Salmeterol Multicenter Asthma Research Trial* A Comparison of Usual Pharmacotherapy for Asthma … -
HS Nelson, ST Weiss, ER Bleecker, SW Yancey, PM … - Chest, 2006 - Am Coll Chest Phys
... systemic disease that in the opinion of the investigator may place a ... Study Design
and Intervention The Salmeterol Multicenter Asthma Research Trial (SMART) was ...

Measures of life quality, role performance, and functional status in asthma research.
JM Richards Jr, MP Hemstreet - Am J Respir Crit Care Med, 1994 - ncbi.nlm.nih.gov
... asthma. Nevertheless, several broad conclusions may be drawn about the use
of measures of these outcomes in asthma research. Asthma ...

Qualitative research and evidence based medicine -
J Green, N Britten? - BMJ, 1998 - pubmedcentral.nih.gov
... process, interaction, and relativism may be shared ... The generalisability of qualitative
research is likely to ... denial of the diagnosis of asthma and medication ...

… da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group -
N Zamel, PA McClean, PR Sandell, KA Siminovitch, … - American Journal of Respiratory and Critical Care Medicine, 1996 - Am Thoracic Soc
... The University of Toronto Genetics of Asthma Research Group. ... 23% had a definitive
diagnosis of asthma (AR+ with ... suggesting that these islanders may also carry ...

The Relationship Between Asthma and Obesity in Urban Minority Children and Adolescents -
J Gennuso, LH Epstein, RA Paluch, F Cerny - Archives of Pediatrics and Adolescent Medicine, 1998 - Am Med Assoc
... energy ex- penditure. This research may provide a basis for im- proved
treatment for asthma in youth. In conclusion, the results ...

… Relationship Between Psychosocial Factors and Asthma Morbidity in Inner-City Children With Asthma -
CM Weil, SL Wade, LJ Bauman, H Lynn, H Mitchell, J … - Pediatrics, 1999 - Am Acad Pediatrics
... Two other psychosocial factors, social support and life stress, also may contribute
to asthma morbidity in children. Previous research has shown a consistent ...

How much asthma is really attributable to atopy? -
N Pearce, J Pekkanen, R Beasley - Thorax, 1999 - pt.wkhealth.com
... commonly assumed may have led to an under-recognition of, and insufficient research
into, other possible aetiological mechanisms for the development of asthma. ...

Obesity May Increase the Incidence of Asthma in Women but Not in Men: Longitudinal Observations from … -
Y Chen, R Dales, M Tang, D Krewski - American Journal of Epidemiology, 2002 - pt.wkhealth.com
... mass and women more fat mass may also contribute to ... by objectively measuring changes
in asthma severity and ... This research was supported by a National Health ...

Difficult/therapy-resistant asthma The need for an integrated approach to define clinical phenotypes … -
F Password - European Respiratory Journal, 1999 - Blackwell Synergy
... The outcome of such desperately needed research may shed light on not only
difficult/therapy resistant asthma but also asthma in general. References. ...

Is Infant Immunization a Risk Factor for Childhood Asthma or Allergy?. -
T Kemp, N Pearce, P Fitzharris, J Crane, D … - Epidemiology, 1997 - JSTOR
... 21 It is therefore theoretically possible that immunization may contribute to ...
infancy,12 or through the From the 'Wellington Asthma Research Group, Department ...

Source: Google Scholar

Research May Lead To Improved Therapeutics Against Asthma
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein -- LTC4 synthase -- which has a major influence on the development of asthma. LTC4 synthase is extremely difficult to analyze, and previously only low resolution information has been available on two membrane protein structures from human. The scientists now believe that their work will enable the development of new and better therapeutics against inflammations in the pulmonary tract.

Asthma attacks are caused by an acute inflammatory reaction in the airways, a reaction that is largely due to actions of LTC4 synthase. For this reason asthma medicines often aim at blocking the downstream effects of LTC4 synthase. However, there is a need for new pharmaceutical alternatives, since not all patients respond to the existing medicines.

Scientists at the Department of Medical Biochemistry and Biophysics have now, with the help of the two EU networks 'EICOSANOX' and 'E-Mep', elucidated the three dimensional structure of the LTC4 synthase at 2.0 -- resolution (1 - = 1 Angstrom = 10-10 m = 0,000 000 000 1 m). It is clear from the structure that the protein has three identical subunits, each of them consisting of four spiral structures that span the nuclear membrane.

Also the exact position and characteristics of the active sites, where activating or blocking molecules can bind, have been identified. With this knowledge it is now possible to tailor new molecules that can block the LTC4 synthase.

The new results are also very important as they can lead the way for the development of new and more effective therapeutics against other diseases. Some 40 % of the proteins of interest for pharmaceutical developments are membrane proteins.

Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function.

The present study is likely to lead the way for the determination of structures of other human membrane proteins. The elucidation of more membrane protein structures will help us understand fundamental processes that take place in the cell membranes.

Facts: Proteins consist of a chain of amino acids.

The length of this chain can range from a few to thousands of amino acids. The chain is then folded in a characteristic way and the 3-D structure can bind different molecules.

Determining a protein structure and its biochemical characteristics helps us understand its function, and to design blocking or activating molecules which can serve as medicines. A known protein structure therefore makes it easier and faster to develop new pharmaceuticals.

The EU network EICOSANOX brings together leading scientists from Europe and Canada, and is coordinated by Karolinska Institutet.

Publication:

"Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase"
Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P.
Nature, AOP 15 July 2007

For more information, please contact:
Professor Jesper Z. Haeggstrom, coordinator for EICOSANOX

Karolinska Institutet is one of the leading medical universities in Europe. Through research, education and information, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine. For more information, visit http://ki.se/

Source: Professor Par Nordlund
Karolinska Institutet
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.