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Recent News and Articles on the Keywords: resistance + energy + alters  Related to the article below (Last Update: 8/5/2008)

Duke opposes Save-A-Watt alternative The Business Journal of the ...
Bizjournals.com, NC - Jul 31, 2008
This would radically alter traditional regulatory policy in North Carolina and the idea has run into considerable resistance. Opponents, who have proved ...DUK

Greentech Media
Biofuels and Electricity Take Out the Trash
Greentech Media, MA - Jul 29, 2008
Mark Mentemurro, CEO of Calgary-based Alter NRG, a supplier of plasma-gasification systems that produce syngas from waste, said he doesn't want to tie his ...
Fake Inflation Statistics and the New World Order Heralds Class ...
The Market Oracle, UK - Aug 3, 2008
Just last week the ?Doha Round? of WTO trade talks collapsed at Geneva when India and China led the way in refusing to alter their tariff and subsidy ...
The Oceanic Crisis: Capitalism and the Degradation of Marine ...
RedOrbit, TX - Aug 3, 2008
It boasts of having ownership from "egg to plate" and substantially alters the ecological and human dimensions of a fishery.32 Aquaculture (sometimes also ...

MinnPost.com
Bridge as symbol: It first served as an alarm, then as a reminder
MinnPost.com, MN - Aug 1, 2008
Moreover, human nature resists change, and resistance to new energy, transportation and land-use policies will be massive. News reports are filled nowadays ...

New York Times
Famed Name Is Double-Edged as Two Udalls Run
New York Times, United States - Jul 7, 2008
They contend that the Udalls? resistance to new drilling and to wringing oil out of Rocky Mountain shale has contributed to the energy cost squeeze. ...
Need luck in your relationship? Do this home ritual
Inquirer.net, Philippines - Jul 15, 2008
Despite her resistance, we disposed of all the old and meaningless items she was attached to. The influx of new furniture, appliances, linen and decor for ...
2008: Year of Emergence
OpEdNews, PA - Jul 28, 2008
Our civilizational trajectory possesses immense inertia, or resistance to change in its present trajectory. Our civilization is based on hydrocarbon energy, ...
Nanomechanical Testing of Polymeric Materials using Nanotest ...
AZoNano.com, Australia - Jul 26, 2008
The draw process induces crystallinity and orientational changes which alter the mechanical properties. Figure 8. Correlation between the variation in ...
A Blog For All and No One
ScienceBlogs - Jul 29, 2008
Zuska is the kick-ass alter-ego of Suzanne E Franks. When not dispensing Zuska's wisdom, Suzanne can often be found gardening, reading, or having one of her ...
Source: Google News

Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity … -
LH Storlien, DE James, KM Burleigh, DJ Chisholm, … - American Journal of Physiology- Endocrinology And Metabolism, 1986 - Am Physiological Soc
... page L. Mantha and Y. Deshaies Energy intake-independent ... traits of obesity-prone
and obesity-resistant rats on ... and MJ Meaney High-fat feeding alters both basal ...

Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats -
MJ Pagliassotti, PA Prach - American Journal of Physiology- Regulatory, Integrative and …, 1995 - Am Physiological Soc
... Quantity of sucrose alters the tissue pattern and time course of insulin resistance
in young ... 8/treatment): 1) high-starch diet (68% of total energy) for 8 ...

… Tissue as an Immediate Target of Tumor Necrosis Factor-{alpha}: Implications for Insulin Resistance -
H Ruan, PDG Miles, CM Ladd, K Ross, TR Golub, JM … - Diabetes, 2002 - Am Diabetes Assoc
... plasma FFAs. TNF- later alters systemic energy homeostasis that closely
resembles the insulin resistance phenotype. Our data suggest ...

… Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/ob Mice -
Z Xia, AD Sniderman, K Cianflone - Journal of Biological Chemistry, 2002 - ASBMB
... on ASP action and obesity resistance, we examined ... site of action; however both alter
energy disposition through ... coupled to ASP deficiency alters fat metabolism ...

Leptin increases uncoupling protein expression and energy expenditure -
PJ Scarpace, M Matheny, BH Pollock, N Tumer - American Journal of Physiology- Endocrinology And Metabolism, 1997 - Am Physiological Soc
... stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy
Expenditure in ob ... AA Dunn-Meynell Maternal obesity alters adiposity and ...

Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats -
BE Levin - American Journal of Physiology- Regulatory, Integrative and …, 1999 - Am Physiological Soc
... BE Levin and AA Dunn-Meynell Sibutramine alters the central ... A. INUI Transgenic study
of energy homeostasis equation ... in diet-induced obese and resistant rats Am ...

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration … -
MP MATTSON, WA PEDERSEN, W DUAN, C CULMSEE, S … - Annals of the New York Academy of Sciences, 1999 - Blackwell Synergy
... and metabolic impairment may alter APP processing. ... leads to membrane depolarization,
energy depletion and ... with sAPPa increases their resistance to oxidative ...

Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves … -
S Bluher, S Moschos, J Bullen Jr, E Kokkotou, E … - Diabetes, 2004 - Am Diabetes Assoc
... protein 1 mRNA expression in BAT and energy expenditure in ... the putative point
responsible for leptin resistance in diet ... 6J and UCP1-DTA mice to alter food intake ...

Low energy availability, not stress of exercise, alters LH pulsatility in exercising women -
AB Loucks, M Verdun, EM Heath - Journal of Applied Physiology, 1998 - Am Physiological Soc
... Low energy availability, not stress of exercise, alters LH pulsatility in
exercising women. AB Loucks, M. Verdun, and EM Heath Department ...

… acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance -
SD Clarke - British Journal of Nutrition, 2007 - Cambridge Univ Press
... acids for the maintenance of energy balance and ... its role in fuel partitioning and
insulin resistance. ... 1990) Diet fat composition alters membrane phospholipid ...

Source: Google Scholar

Insulin Resistance Alters Energy Storage, Knowledge Could Prevent Onset Of Metabolic Syndrome
Abdominal fat, the spare tire that many of us carry, has long been implicated as a primary suspect in causing the metabolic syndrome, a cluster of conditions that includes the most dangerous heart attack risk factors: prediabetes, diabetes, high blood pressure, and changes in cholesterol.

But with the help of powerful new imaging technologies, a team of Howard Hughes Medical Institute (HHMI) researchers at Yale University School of Medicine has found that insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome.
Insulin resistance is a condition in which the body's cells become resistant to insulin, a hormone secreted by the pancreas that plays an essential role in regulating the carbohydrates, lipids, and proteins obtained from food.

The new study, published in the Proceedings of the National Academy of Sciences (PNAS), demonstrates that insulin resistance in skeletal muscle -- caused by decreased ability of muscle to make glycogen, the stored form of carbohydrate from food energy -- can promote an elevated pattern of lipids or fats in the bloodstream that underpins the metabolic syndrome.

The study was led by HHMI investigator Gerald I. Shulman and Kitt Falk Petersen, both of the Yale University School of Medicine. Coauthors of the paper were from Yale and Harvard Medical School.

The metabolic syndrome is a very common metabolic abnormality and the prevalence is growing. However, the underlying factors that cause it are poorly understood. The syndrome afflicts more than 50 million Americans and roughly half of all Americans are predisposed to it, making it one of the nation's most serious human health issues.

To begin to shed light on the earliest molecular events that lead to the metabolic syndrome, Shulman and his colleagues used powerful new magnetic resonance imaging techniques to observe how nutrients are channeled in the body in both insulin resistant and insulin sensitive human subjects.

The subjects for the study were all young, lean, non-smoking, healthy individuals who were sedentary and matched for physical activity. Aside from insulin resistance in one cohort, these volunteers had none of the other confounding factors typically associated with obesity and type 2 diabetes, which have been thought to play a key role in the pathogenesis of the metabolic syndrome.

"Our hypothesis was that the metabolic syndrome is really a problem with how we store energy from food," Shulman explained. "The idea is that insulin resistance in muscle changes the pattern of energy storage."
After providing the study's subjects with two meals high in carbohydrates, Shulman and his colleagues turned to magnetic resonance spectroscopy to measure the production of liver and muscle triglyceride, the storage form of fat, and of glycogen, the storage form of carbohydrate. "What we found is that (insulin) sensitive individuals took the energy from carbohydrate in the meals and stored it away as glycogen in both liver and muscle," said Shulman.

In the insulin resistant subjects, the energy obtained from their carbohydrate rich meals was rerouted to liver triglyceride production, elevating triglycerides in the blood by as much as 60 percent and lowering HDL cholesterol (the 'good cholesterol') by 20 percent. "In contrast to the young, lean, insulin-sensitive subjects, who stored most of their ingested energy as liver and muscle glycogen, the young, lean, insulin-resistant subjects had a marked defect in muscle glycogen synthesis and diverted much more of their ingested carbohydrate into liver fat production," Shulman and his colleagues reported.

"What we see," he noted, "is alterations in patterns of energy storage. An additional key point is that the insulin resistance, in these young, lean, insulin resistant individuals, was independent of abdominal obesity and circulating plasma adipocytokines, suggesting that these abnormalities develop later in the development of the metabolic syndrome."

The new findings promise to help untangle the early molecular events of a syndrome at the root of one of the world's most significant health issues. "Knowing how insulin resistance alters energy storage before it leads to more serious problems can help those susceptible prevent the onset of the metabolic syndrome," Shulman said.

Another key observation was that skeletal muscle insulin resistance precedes the development of insulin resistance in liver cells, and that fat production in the liver is increased. "These findings also have important implications for understanding the pathogenesis of nonalcoholic fatty liver disease, one of the most prevalent liver diseases in both adults and children." Shulman said.

The good news, according to Shulman, is that insulin resistance in skeletal muscle can be countered through a simple intervention: exercise.

Source: Jennifer Michalowski
Howard Hughes Medical Institute
 
 
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