Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: drugs + 38,400 + web  Related to the article below (Last Update: 8/5/2008)

Press Conference by Christina Gynna Oguz, Representative, United ...
ReliefWeb (press release), Switzerland - Jul 28, 2008
And more than 320 metric tonnes of food, that's enough for around 38400 Afghans for one month was looted. Despite this WFP will continue food dispatches ...
Boehringer Ingelheim Launches New Powerful Blood Pressure ...
Medical News Today (press release), UK - Jul 8, 2008
Headquartered in Ingelheim, Germany, it operates globally with 137 affiliates in 47 countries and 38400 employees. Since it was founded in 1885, ...
Source: Google News

Schools and Youth Unrest: A Look at Our Basic Educational System and a Description of Two New …
EA Wenk - Invited paper presented at the International Symposium on …, 1971 - ncjrs.gov
... aspx?ID=38400. * A link to the full-text document is provided whenever possible.
For documents not available online, a link to the publisher's web site is ...

[PDF] Proposed Rules Federal Register -
C Cold, B Allergy - edocket.access.gpo.gov
... for submitting comments on the agency Web site. ... Panel reviewed oral and topical nasal
decongestant drug products and ... OTC use (41 FR 38312 at 38399 and 38400). ...

Binocular vision: Seeing in reverse -
IP Howard - Nature, 1997 - nature.com
... by Web Services. ... Search This journal Advanced search. Advertisement. ... News and Views.
Nature 389, 235-237 (18 September 1997) | doi :10.1038/38400. ...

[CITATION] The Domestic Politics of TRIPs: Pharmaceutical Interests, Public Health, and NGO Influence in India
K Das
-

Effective intracellular delivery of oligonucleotides in order to make sense of antisense -
F Shi, D Hoekstra - Journal of Controlled Release, 2004 - Elsevier
... crucial insight into the function and potential regulation of novel genes [6, 7
and 8]. However, there is a growing interest in developing drugs based upon an ...

Enzyme Inhibitors
C Chen, J Yu, BA Fleck, SRJ Hoare, J Saunders, AC … - ingentaconnect.com
... the potency of standard anticholesteremic drug RO 48 ... Web URL: http://www.sciencedirect.
com/science ... de la Selectivite, Domaine Universitaire, 38400 Saint-Martin d ...

System, method, and computer-readable medium for collection of environmental -
V Galliani, TP Joyce, GM Levinson - US Patent 6,904,370, 2005 - freepatentsonline.com
... web page description of its Environmental Monitoring Software ... with US Food and Drug
Administration requirements ... valid values are 2400, 4800, 9600, 14400, 38400. ...

[PDF] NATIONAL NURSE ANESTHETIST WEEK
CCT reviewed California - canainc.org
... of CANA sign up on-line for the secure, members-only side of the web. ... The Medicare
reform and prescription drug package reverses the 4.5% Medicare Part B reim ...

[PDF] Make sense of antisense oligonucleotides -
F Shi, D Hoekstra - On the mechanism of cationic lipid-mediated delivery of … - ub.rug.nl
... regulation of novel genes (6-8). However, there is a growing interest
in developing drugs based upon ... of optimal antisense drugs. ...

Main navigation
Y Langevin, S Dout?, M Vincendon, F Poulet, JP … - Nature, 2006 - nature.com
... Full text access provided to Googlebot Access by Web Services. ... de Plan?tologie de
Grenoble, CNRS/Universit? Joseph-Fourier, Grenoble, 38400, France; ...

Source: Google Scholar

Exploiting interactions between food and drugs could dramatically lower the rapidly rising costs of several anticancer drugs, and perhaps many other medications, two cancer-pharmacology specialists suggest in a commentary in the July 16, 2007, issue of the Journal of Clinical Oncology.
University of Chicago oncologists Mark Ratain, MD, and Ezra Cohen, MD, call attention to the flip side of recent studies showing how certain foods can alter absorption or delay breakdown of precisely targeted anti-cancer drugs.

Instead of seeing such studies as highlighting a dosing problem, Ratain and Cohen argue that results like this one should point researchers toward a partial solution, a novel way to decrease medication costs while increasing benefits from these effective but expensive drugs.
The commentary was inspired by a study presented in June at the American Society for Clinical Oncology. Researchers from Dartmouth showed that taking the breast cancer drug lapatinib (TYKERB) with food instead of on an empty stomach as suggested on the label resulted in more of the drug being absorbed and available to treat the cancer.

Patients currently take five 250 mg lapatinib tablets on an empty stomach. The study found that taking the drug with a meal increased the bioavailability of the drug by 167 percent. Taking the drug with a high-fat meal boosted levels by 325 percent.

"Simply by changing the timing, taking this medication with a meal instead of on an empty stomach, we could potentially use 40 percent (or even less) of the drug," said Ratain. "Since lapatinib costs about $2,900 a month, this could save each patient $1,740 or more a month."

Topping off that meal with grapefruit juice, "which may also increase plasma concentrations" according to the package insert, could increase the savings to 80 percent, the authors suggest, "minus the cost of the food and juice."

"We expect the one 250 mg lapatinib pill accompanied by food and washed down with a glass of grapefruit juice may yield plasma concentrations comparable to five 250 mg pills on an empty stomach," Ratain said.

Such a "value meal," the authors add, may have other benefits. The major toxicity associated with lapatinib is diarrhea, probably caused by unabsorbed drug. So taking a lower dose with food should "reduce the amount of unabsorbed drug, and therefore theoretically also reduce the frequency and severity of diarrhea."

Patients should NEVER launch such experiments on their own, the authors caution. Such food-drug combinations should be studied to assess the effects, note person-to-person variations, and enable physicians to predict how individual patients will take up and metabolize specific drugs in the presence of certain foods.

"The one thing that should not be anticipated is an efficacy study by lapatinib's sponsor," the authors write. Such studies could be mounted by other entities, however, such as the Federal government, other payers or advocacy groups.

Ratain and Cohen are currently conducting such a study, a phase I trial of the combination of oral sirolimus (rapamycin) taken with grapefruit juice, which contains substances that delay the breakdown of many drugs.

Dozens, perhaps hundreds, of drugs ought to be studied in this way, the authors said. "If we understood the relationship between, say, grapefruit juice and common drugs, such as the statins, which taken daily by millions of people to prevent heart disease, we could save a fortune in drug costs," Cohen said. "And patients would get a little vitamin C to boot."

"The rapidly escalating price of medications (especially for cancer and other life-threatening diseases) has provided incentives to explore pharmacological approaches to lower the costs of drugs," Ratain and Cohen conclude.

"As we enter an era of 'targeted' anticancer agents with a monthly cost measured in thousands of dollars, we should view drug-drug or drug-food interactions as opportunities to lower costs."

University of Chicago Medical Center
MC 6063, 5841 S. Maryland Ave.
Chicago, IL 60637
United States
http://www.uchospitals.edu
 
 
 
Google
Web www.iconocast.com

Search inside Iconocast for the keyword you have in mind.

Iconocast has collected more than 50,000 articles and press releases on health and science.

These are current and most up to date press releases on the subject you are searching.

We collect current health and science press releases daily from more than 5000 research and health institutes. Here is an example : The elderberry way to perfect skin

We believe if you do search inside Iconocast, you will get better results than searching the web alone.

 
 
Continue News With: News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

Contact Iconocast

© 2003-07. ICONOCAST is a trademark of iconocast.com.