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Recent News and Articles on the Keywords: rna + interference + processes  Related to the article below (Last Update: 8/5/2008)


Earthtimes (press release)
Regulus Therapeutics Appoints Garry Menzel, Ph.D., as Executive ...
Business Wire (press release), CA -
Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is applying its therapeutic expertise ...
Alnylam Consolidates Intellectual Property for RNA Activation ... Genetic Engineering News (press release)
all 18 news articles »  ALNY - ISIS - ATH:ASCO
Nobel laureates to tackle global issues
The Daily Yomiuri, Japan - Aug 1, 2008
RNA interference occurs in both plants and animals. Experts say the process is important for the regulation of gene expression, defense against viral ...

Oneindia
Antibiotics To Enhance RNA
Oneindia, India - Jul 23, 2008
A class of antibiotics, known as fluoroquinolones can enhance RNA interference, the gene-silencing tool that can treat a variety of diseases if adapted in ...
Scientists identify antibiotics to enhance gene-silencing tool Fresh News
all 5 news articles »
Dicerna Pharmaceuticals, a Second Generation RNA Interference ...
Business Wire (press release), CA - Jul 15, 2008
In humans, Dicer optimally processes double-stranded RNA oligonucleotides of 25 to 30 base pairs, resulting in a 5-to-100-fold more potent activity and ...
Dicerna Pharmaceuticals Raises Another $8.4 Million for Next ... Xconomy
all 18 news articles »

Business Wire (press release)
MDRNA, Inc. Demonstrates In Vivo Efficacy with Proprietary DiLA 2 ...
Business Wire (press release), CA - Aug 1, 2008
One of the intermediate steps in RNA interference involves the loading of small, double-stranded RNA duplexes (siRNAs) into the RNA Induced Silencing ...MRNA
U. Washington Team Uses Mass Spec To Find 63 Novel Proteins in Fly ...
Proteo Monitor, NY - Jul 31, 2008
?One thing that we?re starting ? to ask [is] ?If you knock down using RNA interference one of the proteins, does that have an effect on how well the male ...
Evidence of the role of tick subolesin in gene expression
7thSpace Interactive (press release), NY - Aug 2, 2008
Results: Two subolesin-interacting proteins were identified and characterized by yeast two-hybrid screen, co-affinity purification and RNA interference ...
Roche boosts RNAi capability with acquisition of Mirus Bio Corporation
MTBeurope, UK - Aug 1, 2008
RNAi (RNA interference) is a revolution in biology, representing a breakthrough in understanding how genes are turned on and off in cells. ...
Alnylam Announces Extension of RNAi Therapeutics Collaboration ...
MarketWatch - Jul 16, 2008
RNAi (RNA interference) is a revolution in biology, representing a breakthrough in understanding how genes are turned on and off in cells, and a completely ...NVS - ALNY

WELT ONLINE
Alnylam Provides Update on "Glover" Patent
WELT ONLINE, Germany - Jul 10, 2008
About RNA Interference (RNAi) RNAi (RNA interference) is a revolution in biology, representing a breakthrough in understanding how genes are turned on and ...ALNY - ISIS
Source: Google News

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. -
SM Elbashir, J Harborth, W Lendeckel, A Yalcin, K … - Nature, 2001 - ncbi.nlm.nih.gov
... RNA interference (RNAi) is the process of sequence-specific, post-transcriptional
gene silencing in animals and plants, initiated by double-stranded RNA (dsRNA ...

[PDF] The rde-1 gene, RNA interference, and transposon silencing in C. elegans -
H Tabara, M Sarkissian, WG Kelly, J Fleenor, A … - Cell, 1999 - colorado.edu
... Interestingly, several, but not synthesis in this gene silencing process (Cogoni
and ... Here, we report the identification of RNA interference- ...
-

… Anatomy of a dsRNA Trigger Differential Requirement for the Two Trigger Strands in RNA Interference -
S Parrish, J Fleenor, SQ Xu, C Mello, A Fire - Molecular Cell, 2000 - Elsevier
... the interference process; the simplest interpretation would be to propose that the
antisense strand of the trigger could interact directly with the target RNA, ...

RNA interference---2001 -
PA Sharp - Genes & Development, 2001 - Cold Spring Harbor Lab
... In the few years since the discovery of RNA interference (RNAi; Fire et al.
1998 ), it has become clear that this process is ancient. ...

[PDF] RNA interference -
GJ Hannon? - Nature, 2002 - genesil.com
... What are the biological functions of these processes? And how are they related in
evolutionarily divergent fungi, plants and animals? ... RNA interference ...
-

… in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference -
M Jiang, J Milner - Oncogene, 2002 - nature.com
... It is therefore possible that RNA interference may cause imbalance within normal
cellular biochemical processes and regulatory systems. ...

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference -
AG Fraser, RS Kamath, P Zipperlen, M Martinez- … - Nature, 2000 - palgrave-journals.com
... analysis of the C. elegans genome has shed light on many conserved biological processes
and molecular ... RNA-mediated interference (RNAi) transiently ...

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
A Fire, S Xu, MK Montgomery, SA Kostas, SE Driver, … - Nature, 1998 - nature.com
... RNA-targeted processes cannot, however, be ruled out, as they could include a catalytic
component. Alternatively, direct RNA-mediated interference at the level ...
-

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing … -
RF Ketting, SEJ Fischer, E Bernstein, T Sijen, GJ … - Genes & Development, 2001 - Cold Spring Harbor Lab
... Double-stranded RNAs can suppress expression of homologous genes through an
evolutionarily conserved process named RNA interference (RNAi) or post ...

RNA interference is mediated by 21-and 22-nucleotide RNAs -
SM Elbashir, W Lendeckel, T Tuschl - Genes & Development - Cold Spring Harbor Lab
... Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene
silencing in many organisms by a process known as RNA interference (RNAi). ...

Source: Google Scholar

RNA Interference Decision-Making Processes On A Molecular Level
"How does RNAi work?" Researchers across the world have been trying to answer this question for a number of years. Science has now come closer to finding the answer thanks to a research group headed by Prof. Renée Schroeder (MFPL) and Dr. Javier Martinez (IMBA) based at the Campus Vienna Biocenter. The group's results are being published today in the internationally renowned scientific journal CELL and underline the importance of Austrian RNA research, which is also supported by the Austrian Science Fund FWF.
RNA interference (RNAi) is a natural cellular defence and regulation mechanism which works by eliminating unwanted RNA molecules. Its potential for use in therapy was officially recognised last year with the presentation of the Nobel Prize in Physiology or Medicine. Indeed, the first treatments to be based on this mechanism are currently undergoing clinical testing. Nevertheless, the details of this process still require a great deal of further research and hence, offer potential for optimizing medical treatments based on it.

No Risc. No Fun

It is precisely this potential that a group at the Campus Vienna Biocenter recently tapped in order to clarify key details surrounding the efficiency of RNA interference. Lead scientist Dr. Stefan L. Ameres from the Max F. Perutz Laboratories (MFPL), Department for Biochemistry at the University of Vienna, explains "A key stage of RNA interference is the binding of the RNA that is to be cleaved by RISC, the RNA-induced silencing complex. Already a lot is known about the subsequent destruction of the target RNA by RISC, but we have only little insight into the initial determination as to which RNAs are bound and how exactly this happens. Working with the Institute for Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), we have succeeded in making considerable progress towards clarifying this process."

The team initially focussed on characterising the influence of the RNA structure. Variations of an RNA target molecule were created where the RISC binding site became increasingly difficult to access due to structural differences. Dr. Ameres comments on the findings from the experiment: "The results were very clear indeed. The less accessible the binding site, the less efficient the RISC-induced elimination of the target RNA. Based on this data, we concluded that RISC does not possess the means to change the structure of RNA molecules an important finding towards the effective application of RNAi."
Another result was equally important to the understanding of RNA interference. The strength of the interaction between target RNA and RISC must exceed a certain threshold in order to trigger initiation of the subsequent RNA elimination process. This result clearly indicates that RISC binds RNA in a more or less random process and that it is the strength of this bond that determines the subsequent fate of the RNA. "One way of looking at this is that, while binding its target RNA, RISC has to carry out a check to ensure that it is only certain RNAs that are destroyed," explains Dr. Ameres.

"Ph.D. Program" Career Opportunity

The publication of these results in the journal CELL highlights not just the quality of RNA research at the Max F. Perutz Laboratories (a joint establishment of the University of Vienna and the Medical University of Vienna), but also the high standard of training provided for young scientists in dedicated Ph.D. programs. The publication of these results is also the high point of Dr. Ameres' Ph.D. training, which he has now completed in just this type of program. In fact, a special "RNA Biology" Ph.D. program was established at the Campus Vienna Biocenter in June 2007 to ensure that RNA research there retains its leading position in the long term. The work of molecular biologist Prof. Renée Schroeder also contributed to this achievement. She supported the work of Dr. Ameres using the prize money from the "Wittgenstein Award" presented to her by the FWF in 2003, thereby making an important financial contribution to the continuation of RNA research at the Campus Vienna Biocenter.

Click here to see image and text

" Molecular Basis for Target RNA Recognition and Cleavage by human RISC"
S.L. Ameres. J. Martinez, R. Schroeder
CELL (2007). doi:10.1016/j.cell.2007.04.037
Universität Wien
Campus Vienna Biocenter 5
1030 Vienna, Austria
http://www.univie.ac.at

Austrian Science Fund FWF
 
 
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