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Recent News and Articles on the Keywords: prostate + cancer + highly  Related to the article below (Last Update: 8/5/2008)


E Canada Now
Benefit Of PSA Screening For Cancer Challenged By Task Force
Hartford Courant, United States -
That was the conclusion Monday of a highly respected federal task force making the first update of its recommendations for prostate cancer screening in five ...
Panel Urges End to Prostate Screening at Age 75 New York Times
all 319 news articles »
OR-Live Presents: The Road to Recovery From Prostate Cancer Begins ...
MarketWatch - Jul 30, 2008
Robotic prostate surgery is driven by highly magnified visual enhancement technology in a bloodless field. The result is greater precision in cutting and ...ISRG - OTC:CMTX
/REPEAT -- Diagnocure announces the formation of a new Strategic ...
Canada NewsWire (press release), Canada -
... development and commercialization of a second- generation test for PCA3, DiagnoCure's proprietary molecular marker highly specific to prostate cancer. ...TSE:CUR - GPRO

BBC News
Prostate cancer drug hailed as breakthrough
New Zealand Herald, New Zealand - Jul 22, 2008
Scientists are hailing the drug, called abiraterone, as a major breakthrough in the treatment of highly aggressive prostate cancer which, before now, ...
New pill helps shrink prostate tumors: study Reuters
New prostate cancer drug offers hope TVNZ
Prostate cancer drug gives hope to 'untreatable' patients Independent
Western Morning News
all 491 news articles »
See health in black, white and green
Hagerstown Morning Herald, MD - Aug 4, 2008
Jovel said the hospital recently received a grant to establish an outreach program to raise awareness about the importance of prostate cancer screening for ...
Radiation an effective option for prostate cancer
Enid News & Eagle, OK - Jul 28, 2008
A computer guides the placement of 80 to 120 radioactive seeds smaller than a grain of rice directly into the prostate. A highly concentrated dose is ...
Hormone Therapy In Prostate Cancer Treatment May Lead To Cognitive ...
eMaxHealth.com, NC - Jul 30, 2008
... and goserelin to achieve androgen depletion and to boost hormones like testosterone, which are highly effective in targeting prostate cancer cells. ...
Cutting-Edge Care
RedOrbit, TX - Aug 4, 2008
The new biplane imaging technology will allow the hospital to provide this highly specialized care to more people locally. Goshen Center for Cancer Care, ...
A new drug offers advances in cancer treatment
Times Online, UK - Jul 27, 2008
Although prostate cancer affects more than 35000 men annually and kills 10000, at that time less money was spent each year by the NHS on research into ...
Donedei Wines to Host Charitable Event for Robotic-Assisted ...
MarketWatch - Jul 17, 2008
When Fred Goldberg, co-founder of Donedei Wines, www.donedei.com, was diagnosed with prostate cancer, he became one of the fortunate Washington state ...
Source: Google News

Loss of PTEN Expression in Paraffin-embedded Primary Prostate Cancer Correlates with High Gleason … -
ME McMenamin, P Soung, S Perera, I Kaplan, M Loda, … - Cancer Research, 1999 - AACR
... Clinical Investigations. Loss of PTEN Expression in Paraffin-embedded Primary Prostate
Cancer Correlates with High Gleason Score and Advanced Stage 1. ...

Immunohistochemical Demonstration of Phospho-Akt in High Gleason Grade Prostate Cancer -
SN Malik, M Brattain, PM Ghosh, DA Troyer, T … - Clinical Cancer Research, 2002 - AACR
... Molecular Oncology, Markers, Clinical Correlates. Immunohistochemical Demonstration
of Phospho-Akt in High Gleason Grade Prostate Cancer 1. ...

Gene expression correlates of clinical prostate cancer behavior -
D Singh, PG Febbo, K Ross, DG Jackson, J Manola, C … - Cancer Cell, 2002 - Elsevier
... Contemporary identification of patients at high risk of early prostate cancer
recurrence after radical retropubic prostatectomy. Urology 57, pp. ...

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search -
JR Smith? - Science, 1996 - sciencemag.org
... A genome-wide scan performed in 66 high-risk prostate cancer families has provided
evidence of linkage to the long arm of chromosome 1 (1q24-25). ...

Effect of high-intensity focused ultrasound on human prostate cancer in vivo -
S Madersbacher - Cancer Research, 1995 - AACR
... focused ultrasound (HIFU) was recently established as a highly effective means ... therefore,
appears potentially useful for treating localized prostate cancer (PC ...

DD3:: A New Prostate-specific Gene, Highly Overexpressed in Prostate Cancer 1 -
MJG Bussemakers, A van Bokhoven, GW Verhaegh, FP … - Cancer Research, 1999 - AACR
... Cancer Research Molecular Biology and Genetics. DD3::A New Prostate-specific
Gene, Highly Overexpressed in Prostate Cancer 1. Marion JG ...

… alterations in untreated metastases and androgen-independent prostate cancer detected by comparative … -
ML Cher - Cancer Research, 1996 - AACR
... These samples, which contained highly enriched tumor DNA, showed the highest ... chromosomal
regions known to be altered frequently in prostate cancer: 8q gain (85 ...

Trp-p8, a Novel Prostate-specific Gene, Is Up-Regulated in Prostate Cancer and Other Malignancies … -
L Tsavaler, MH Shapero, S Morkowski, R Laus - Cancer Research, 2001 - AACR
... it has been shown that Drosophila trp proteins, which highly resemble human trp ... its
role in regulating metastatic potential of prostate cancer, are currently ...

Prostate cancer radiation dose response: results of the MD Anderson phase III randomized trial. -
A Pollack, GK Zagars, G Starkschall, JA Antolak, … - Int J Radiat Oncol Biol Phys, 2002 - ncbi.nlm.nih.gov
... 78 Gy in controlling prostate cancer. ... was defined as 3 rises in the prostate-specific
antigen ... arm, Grade 2 or higher rectal toxicity correlated highly with the ...

Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer -
MG Harisinghani, J Barentsz, PF Hahn, WM Deserno, … - The New England Journal of Medicine, 2003 - nejm.org
... lymph-node metastases in prostate cancer is an essential component of the approach
to treatment. We investigated whether highly lymphotropic superparamagnetic ...
-

Source: Google Scholar

EPCA-2: A Highly Specific Serum Marker For Prostate Cancer
UroToday.com- The steady decrease in prostate cancer mortality is indirect evidence that prostate cancer early detection using serum PSA and the digital rectal examination saves lives. Nevertheless, the use of serum PSA for prostate cancer screening remains controversial due to its low specificity. Developing additional serum tumor markers for early detection would prove invaluable for improving early detection while reducing the number of unnecessary biopsies.

In the April issue of Urology, Leman and colleagues describe the performance characteristics of EPCA-2, a novel nuclear protein marker for prostate cancer cells. EPCA and EPCA-2 were identified at Johns Hopkins using proteomic technology to analyze the subcellular protein composition of prostate cancer cell nuclei.
Banked serum from several subsets of patients was used including: 63 men with a serum PSA less than 2.5 ng/ml and a normal DRE (30 of those had undergone a negative 12-core biopsy), 80 men with prostate cancer (40 organ-confined and 40 non-organ confined), 35 men with symptomatic BPH, and men with prostate cancer and PSA levels less than 2.5 ng/ml and (5) 134 controls.

In men without cancer, the EPCA-2.22 ELISA assay had 92% specificity (95% CI, 85% to 96%) and 94% sensitivity (95% CI, 93% to 99%) for prostate cancer using a threshold value of 30 ng/mL. In men with a diagnosis of prostate cancer, EPCA was found to have a sensitivity of 90% and 98% in men with organ confined and non-organ confined disease, respectively. Interestingly, the EPCA-2.22 serum assay was effective in differentiating patients with localized disease versus extraprostatic extension with an area under the curve of 0.89 (p < 0.0001).

This exciting study suggests that the EPCA-2 protein serum assay exhibits favorable performance characteristics which are potentially superior to serum PSA. Whether this test will retain its sensitivity and specificity when used in a screening population remains to be studied.

Leman ES, Cannon GW, Trock BJ, Sokoll LJ, Chan DW, Mangold L, Partin AW, Getzenberg RH

Urology. 69(4):714-20, April 2007
doi:10.1016/j.urology.2007.01.097

Reported by UroToday.com Contributing Editor Ricardo F. Sánchez-Ortiz, MD

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.

To access the latest urology news releases from UroToday, go to: www.urotoday.com
 
 
 
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