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Recent News and Articles on the Keywords: genome + human + 344,000  Related to the article below (Last Update: 8/5/2008)


Science a Gogo
Human Brains Pay A Price For Being Big
Science Daily (press release) -
Research published today in BioMed Central's open access journal Genome Biology adds weight to the theory that schizophrenia is a costly by-product of human ...
Schizophrenia costly byproduct of brain evolution IndiaEduNews.net
all 17 news articles »
Sequenom Certifies McGill University and Genome Quebec Innovation ...
Stockhouse, Canada -
... such as screening tests, therapeutic tools in human health or new environmental procedures in agriculture and forestry. The funds invested by Genome ...SQNM
Human Genome Sciences reports stronger sales, bigger losses
Bizjournals.com, NC - Aug 1, 2008
Human Genome Sciences Inc. increased its second-quarter revenue by 28 percent from the same period last year, but also widened its loss by nearly 45 percent ...HGSI
Next Generation Tool For Visualizing Genomic Data Introduced
Science Daily (press release) -
... those relevant to human disease," said Reich. "We're particularly excited about its already groundbreaking use in ongoing studies of the cancer genome."
Human Genome Sciences Inc (HGSI) holdings reduced by Profund ...
Mffais.com, CA - Aug 2, 2008
LONG BEACH (Mffais.com) - Profund Advisors Llc sold -8421 (-19.39 %) of their shares in Human Genome Sciences Inc (HGSI), bringing their current holdings to ...HGSI
Genetic Evidence Used To Trace Ancient African Migration
Science Daily (press release) -
Henn, Mountain and Underhill collaborated with scientists at the Stanford Genome Technology Center; the University of Regensburg, in Germany; ...
New genome sequencing projects announced
United Press International -
... culled from nearly 150 proposals and represent more than 60 billion nucleotides of data to be generated -- roughly the equivalent of 20 human genomes. ...
Human Genome Sciences Announces Second Quarter 2008 Financial ...
MarketWatch - Jul 30, 2008
HGS, Human Genome Sciences, ABthrax, Albuferon and LymphoStat-B are trademarks of Human Genome Sciences, Inc. This announcement contains forward-looking ...
Human Genome Sciences Announces Second Quarter 2008 Financial ... SunHerald.com
all 11 news articles »  HGSI
University of Wisconsin researchers get grant to study stem cells
Milwaukee Journal Sentinel, WI -
A third group led by blood expert Igor Slukvin and Genome Center scientist Junying Yu, who led the reprogramming effort in Thomson?s lab, will examine how ...
NEW $8.9 MILLION PROJECT AIMS TO UNLOCK STEM CELL SECRETS Wisbusiness.com
all 5 news articles »
My Body, My Capital? (by Donna Dickenson)
Journal of Turkish Weekly, Turkey - 12 minutes ago
One in five human genes is now patented, even though the human genome might be thought to be our common heritage. And although Boyle doesn?t mention this ...
Source: Google News

Cosmid clones and their application to genome studies
AC IVENS, PFR LITTLE - DNA Cloning: A Practical Approach, 1995 - books.google.com
... To put this in perspective, a complete human library, as ... of Clarke and Carbon (29),
requires 344000 cosmids for ... a vector capacity of 40 kb and a genome size of ...

Polymorphisms of genes controlling homocysteine/folate metabolism and cognitive function. -
S Barbaux, R Plomin, AS Whitehead - NeuroReport, 2000 - neuroreport.com
... well as environmental factors [1]. Systematic genome scans have ... frequency of about
1 in 344000 live births ... risk factor for several human pathologic conditions ...

Nondependence of diffusion-controlled peak dispersion on diffusion coefficient and ionic mobility in … -
E Kenndler, C Schwer - Analytical Chemistry, 1991 - pubs.acs.org
... Instrumentation and Instrument Development Program (Grant DIR 8908096), and the
National Institutes of Health, National Center for Human Genome Research (Grant ...

Identification of compositionally distinct regions in genomes using the centroid method -
I Rajan, S Aravamuthan, SS Mande - Bioinformatics, 2007 - Oxford Univ Press
... in the following regions: 330001?344000, 364001?378000 ... IL-4 2 mRNA isoform in human
gastric mucosa ... Capturing whole-genome characteristics in short sequences ...

Characteristics of equilibrium, kinetics studies for adsorption of Hg (II), Cu (II), and Ni (II) …
L Zhou, Y Wang, Z Liu, Q Huang - J Hazard Mater, 2008 - ncbi.nlm.nih.gov
... 56, Fuzhou, Jiangxi 344000, PR China; School of Chemistry and Chemical Engineering,
Tianjin University, Weijin Road No. 92, Tianjin 300072, PR China. ...

Gene expression profiles in breast tumors regarding the presence or absence of estrogen and … -
MA Nagai, N da Ros, MM Neto, SR de Faria Junior, … - International Journal of Cancer, 2004 - doi.wiley.com
... MATERIAL AND METHODS Tissue samples Samples of human primary breast ... of mouse tumor
differentially expressed 1 HS.344000 AK026100 Hypothetical ... genome.uscs.edu. ...

?????
??? - ?????, 2005 - scholar.ilib.cn
... ????:???(?????????,??,??,344000) ... regulator element in
the eukaryotic genome. ... and relevance to human diseases.Am J ...
-

Growth regulating proteins -
E Hafen, H Stocker, P Daram, B Shindelholz, S … - US Patent 7,192,706, 2007 - freepatentsonline.com
... EBV-hybridoma technique to produce human monoclonal antibodies ... They performed a
genome-wide screen for ... kb within scaffold AE003738 (nucleotides 344000 464000). ...

Source: Google Scholar

Recent Changes Discovered In The Human Genome

A Cornell study of genome sequences in African-Americans, European-Americans and Chinese suggests that natural selection has caused as much as 10 percent of the human genome to change in some populations in the last 15,000 to 100,000 years, when people began migrating from Africa.

The study, published inPLoS (Public Library of Science) Genetics, looked for areas where most members of a population showed the same genetic changes. For example, the researchers found evidence of recent selection on skin pigmentation genes, providing the genetic data to support theories proposed by anthropologists for decades that as anatomically modern humans migrated out of Africa and experienced different climates and sunlight levels, their skin colors adapted to the new environments.
However, the study found no evidence of differences in genes that control brain development among the various geographical groups, as some researchers have proposed in the past.

"We undertook a very careful study of genetic differences within and among major human groups, and aimed to explain why certain parts of the genome differed," said Scott Williamson, the study's lead author and a Cornell assistant professor of biological statistics and computational biology. "We aimed to eliminate as many possible confounding variables as possible, and when all is said and done, we find that as much as 10 percent of the genome may have been affected by one of these bouts of recent selection."

Previous studies at Cornell and elsewhere have searched for signs of selection -- the divergence of genes from a common ancestor millions of years ago -- by comparing an individual human to a chimpanzee or mouse, for example, or by comparing genetic variation in protein coding genes among humans to differences between humans and a chimpanzee. But this study scanned genome sequences that compared many humans to each other throughout the entire genome, with new strict statistical methods that correct for many potential biases that creep into this kind of analysis.

In the latest study, the researchers identified 101 regions of the human genome with strong evidence of very recent selection. These regions include genes that control proteins that help muscle cells attach to surrounding cells (mutations of this gene lead to muscular dystrophy), receptors that relate to hearing, genes involved in nervous system function and development, immune system genes and heat shock genes.

The gene scan method also detected selection in a gene involved in digestion of lactose, an enzyme found in milk. Prior to animal domestication, humans lost the ability to digest milk after infancy. But, as humans migrated and domesticated animals, Europeans and other populations developed a gene for tolerating lactose (and milk) throughout their lives. This finding has been well established in previous research, so arriving at similar results provided an internal validation for the accuracy of the new method.
Overall, close to 10 percent of the Chinese and European-American genomes and only 1 percent of the African-American genome were linked to areas with evidence of recent selection. Since Africans have the greatest genetic diversity and the statistical method searched for areas where the majority of members within a population group have the same genetic changes, signs of evolution were much easier to detect in the less diverse European-American and Chinese genomes.

"It is important to emphasize that the research does not state that one group is more evolved or better adapted than another," said co-author Carlos Bustamante, a Cornell assistant professor of biological statistics and computational biology. "Rather as humans have populated the world, there has been strong selective pressure at the genetic level for fortuitous mutations that allow digestion of a new food source or tolerate infection by a pathogen that the population may not have faced in a previous environment."

Rasmus Nielsen, an adjunct professor of biological statistics and computational biology at Cornell and now a professor at the University of Copenhagen, Denmark, is the paper's senior author.

Source: Blaine Friedlander
Cornell University News Service
 
 
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