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Recent News and Articles on the Keywords: better + lead + web  Related to the article below (Last Update: 8/5/2008)

Better browsing on mobiles
iTWire, Australia -
... guidelines and maturing tools to help them create a better mobile Web experience," said Dominique Haza?l-Massieux, W3C's mobile web activity lead. ...
Market Place Motorola Names Leader for Mobile Phone Unit
New York Times, United States -
While Mr. Jha provides a much-needed injection of knowledge about the mobile Web, he is an unusual choice because his background is in cellphone ...MOT - QCOM
Microsoft Silverlight Ready For Olympics Closeup
CRN, NY -
8, the Silverlight-powered NBCOlympics.com Website on MSN will go live with event coverage and features that go beyond the typical Web video experience, ...
Clemson named home to happiest college students
Kansas City Star, MO -
The school posted the ranking on its Web site. And a glowing student was on the phone to talk about it within minutes of a reporter's request. ...
Changing the fat
Coalinga Record, CA -
These deposits, too much of which can lead to higher risk for heart disease, can reduce blood flow through the arteries, the Mayo Clinic Web site reports. ...
Prius race is a gas
Arizona Republic, AZ -
On June 30, he was doing even better at 58.5 mpg. He scans Prius Web sites, where owners offer advice on how to improve gas mileage. ...

ABS CBN News
With rise in China's Internet use, more security threats seen
ABS CBN News, Philippines -
He noted that most of the recent Web threats are originating from China, which now has the largest population of Web users in the world at 220 million. ...OTC:TMICY
Software a 'boot Camp' for the Brain
PC World -
Not only that, but he's trying to convince me that Lumosity, the Web-based "brain-training" software made by his company, Lumos Labs, is the answer. ...

Phones Review
Mobile Web Best Practices finally announced by W3C
Phones Review, UK - Aug 4, 2008
W3C Mobile Web Activity Lead, Dominique Haza?l-Massieux, says: ?Mobile Web content developers now have stable guidelines and maturing tools to help them ...

New York Times
'Net neutrality' victory in Comcast case may be temporary
Middle East North Africa Financial Network, Jordan -
Web surfers may want to pause before cheering, though, as some are warning that the move could lead the way to Internet metering -- under which people could ...
TKO of Comcast Sets Stage for a Better Internet Huffington Post
FCC: Comcast Violated Internet Open-Access Guidelines Broadcasting & Cable
all 968 news articles »  CMCSA
Source: Google News

Does Doing Good Always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility -
S Sen, CB Bhattacharya - Journal of Marketing Research, 2001 - Am Marketing Assoc
... Does Doing Good Always Lead to Doing Better? ... The Web sites of more than 80% of the
Fortune-500 companies address CSR issues (Esrock and Leichty 1998). ...

[PDF] Towards a better understanding of Web resources and server responses for improved caching -
CE Wills, M Mikhailov - COMPUT. NETWORKS, 1999 - cs.wpi.edu
... These improvements could lead to better cache hit rates and reduced retrieval latency.
References 1 M. Arlitt and C. Williamson. Web server workload ...

Analysis of anchor text for web search -
N Eiron, KS McCurley - Proceedings of the 26th annual international ACM SIGIR …, 2003 - portal.acm.org
... documents is very useful in improving the quality of web text search ... under- standing
of anchor text for documents will likely lead to better understanding of ...

… Factors This article has been selected for the open discussion forum on the STS Web site: http://www … -
CY Bitkover, B Gardlund - The Annals of Thoracic Surgery, 1998 - Soc Thorac Surgeons
... org/cgi/content/full/65/1/36 the World Wide Web at: The ... An analysis of risk factors
for postopera- tive mediastinitis can lead to a better understanding of ...

Do thumbnail previews help users make better relevance decisions about web search results? -
S Dziadosz, R Chandrasekar - Proceedings of the 25th annual international ACM SIGIR …, 2002 - portal.acm.org
Do Thumbnail Previews Help Users Make Better Relevance ... 1. WEB INFORMATION SEEKING
The interaction between an end ... page and guesses which items will lead to the ...

Using the Internet as a communication infrastructure for lead userinvolvement in the new product … -
PC Muller, R de Poorter, J De Jong, JML Van … - … for Collaborative Enterprises, 1996. Proceedings of the 5th …, 1996 - ieeexplore.ieee.org
... Fiaure 2: Philid PC add-on Lead User Web Site ... As the lead user network evolves, better
selection criteria will become more important for two reasons. ...

Cognitive design of home pages: an experimental study of comprehension on the World Wide Web -
NP Dalal, Z Quible, K Wyatt - Information Processing and Management, 2000 - Elsevier
... This study empirically addresses the issue: do home pages designed according to
theoretical guidelines lead to better comprehension of information at a Web site ...

Crawling a country: better strategies than breadth-first for web page ordering -
R Baeza-Yates, C Castillo, M Marin, A Rodriguez - International World Wide Web Conference, 2005 - portal.acm.org
... [22], and it was found to be better than backlink ... in any Web site, to avoid having
at the end only a small number of large Web sites that may lead to spare ...

[CITATION] Bone lead levels and delinquent behavior -
HL Needleman, JA Riess, MJ Tobin, GE Biesecker, JB … - JAMA: The Journal of the American Medical Association, 1996 - JAMA
... Web browser does not support basic Web standards ... Evolutionary Psychology: toward
a Better Understanding of ... Lead neurotoxicity in children: basic mechanisms and ...

[PDF] Web search using automatic classification -
C Chekuri, MH Goldwasser, P Raghavan, E Upfal - … of the Sixth International Conference on the World Wide Web, 1997 - euler.slu.edu
... As mentioned before, stemming can lead to better training and classification of
documents. ... [NYT96] Desperately Seeking Surfers; web programmers try to alter ...

Source: Google Scholar

Research May Lead To Better Drugs To Fight Deadly Pathogens
Biology textbooks suggest that blunt-neutrophils are mindless killers. These white blood cells patrol the body and guard against infection by bacteria and fungi, identifying and destroying any invaders that cross their path. But new evidence, which may lead to better drugs to fight deadly pathogens, indicates that neutrophils might actually distinguish among their targets.

A scientist in the lab of Whitehead Member Gerald Fink has discovered that neutrophils recognize and respond to a specific form of sugar called beta-1,6-glucan on the surface of fungi. This sugar comprises just a small fraction of the fungal cell wall, much less than another sugar with a slightly different chemical conformation called beta-1,3-glucan. Because the scarce form of the sugar elicits a much stronger reaction from immune cells than the abundant one, it appears that neutrophils can distinguish between two nearly identical chemicals.
"These results show that engulfment and killing by neutrophils varies, depending on cell wall properties of the microbe," explains Whitehead postdoctoral researcher Ifat Rubin-Bejerano, first author on the paper, which appears in the journal Cell Host & Microbe. "We showed that neutrophils respond in a completely different way to slight changes in sugar composition. If we are able to use this unique sugar to excite the immune system, it may help the human body fight infection."

"Previously, everyone thought that these key cells of the immune system weren't picky and would eat anything that looked foreign," adds Fink, who is also an MIT professor of biology. "Ifat's work has shown that the cells aren't little Pac-Men, but can discriminate one pathogen from another."

Rubin-Bejerano had evidence that neutrophils respond to beta-glucan. After coating tiny beads with a variety of substances (including beta-1,3-glucan and beta-1,6-glucan), she exposed them to the neutrophils and was surprised to see a striking difference in their response to the two sugars. The neutrophils quickly engulfed many of the beads coated with beta-1,6-glucan, but only a few of those covered in beta-1,3-glucan.

Previous studies indicated that blood serum (basically blood minus cells) helps neutrophils recognize their enemies, so Rubin-Bejerano decided to look for clues to their response in this mixture. She identified several proteins in serum that bind to beta-1,6-glucan, but not beta-1,3-glucan, and then pinpointed a molecule on the surface of the neutrophil that recognizes these proteins.

To link her experiments back to real fungi, Rubin-Bejerano worked with the pathogen Candida albicans, which is the most common fungus in blood stream infections. She used an enzyme to digest beta-1,6-glucan from the fungal cell wall, leaving the beta-1,3-glucan intact. She then unleashed the neutrophils on these altered cells and observed a 50 percent reduction in the immune response.
Our bodies maintain a fine balance between the immune system and microbes. Antibiotics and antifungals tilt the balance in favor of the immune system by targeting the microbes directly. A substance like beta-1,6-glucan could help tilt this balance further by stimulating immune cells.

Rubin-Bejerano's work offers hope for combating the growing problem of microbial infections, which can seriously threaten human health -- particularly in patients with compromised immune systems. In fact, Rubin-Bejerano co-founded a company called ImmuneXcite to explore this possibility.

Source: Alyssa Kneller
Whitehead Institute for Biomedical Research
 
 
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