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Recent News and Articles on the Keywords: lung transplants + lung transplant + lung  Related to the article below (Last Update: 8/5/2008)


Canton Repository (subscription)
Elliana's life depends on double lung transplant
Canton Repository (subscription), OH -
When they inquired about a bilateral, or double, lung transplant, Elliana's only hope for life, doctors initially told them it was not an option. ...
Double-lung transplant teen back on the farm
Irish Independent, Ireland -
... the 19-year-old from Bagenalstown, Co Carlow made history by becoming the first cystic-fibrosis patient in Ireland to undergo a double-lung transplant. ...
Local Fire Chief Receives Double-Lung Transplant
WGRZ-TV, NY -
Firefighter Dennis Allen received a double-lung transplant at the Cleveland Clinic next month; he's currently still down there and will remain there for at ...
West Lawn girl, 16, thriving two years after double lung transplant
Reading Eagle, PA - Aug 2, 2008
By Ron Devlin When Kaja O'Leary woke up after undergoing a double lung transplant in Children's Hospital of Philadelphia, she complained her new lungs ...
Plan to increase organ donations
The Canberra Times, Australia - Aug 3, 2008
Ms Cahill Lambert is waiting for a lung transplant and said initiatives like this one might increase the number of registered organ donors. ...
Benefit for young girl's lung transplant
MyFox Gulf Coast, AL - Aug 1, 2008
Ashleigh needs a lung transplant. It's hard for her to breathe, she can only ride for about 10 minutes at a time, but her mom said it's the only thing on ...
New virus the culprit in graft rejection
6minutes, Australia - Aug 3, 2008
by Dr Linda Calabresi The recently described human metapneumovirus has been found to be a leading cause of illness in lung transplant patients, according to ...
Lung transplant recipient recovering
Dubuque Telegraph Herald, IA - Jul 31, 2008
Nick LeGrand, 13, received a long-awaited lung transplant during a 13-hour procedure that ended Tuesday. Nick and his mother, Kelly, have been living in ...
Cystic Fibrosis patient awaiting double lung transplant
WAVE, KY - Jul 31, 2008
Megan's biggest battle is yet to come - a double lung transplant scheduled for late this year or early 2009 in St. Louis. "I'm excited because I don't ...
First NY?to?LA Living-Donor Transplant Chain Results in Three ...
Newswise (press release) -
... transplants this year than any other center in the nation. It offers comprehensive and personalized care for the heart, liver, pancreas, kidney and lung ...
Source: Google News

Results of single and bilateral lung transplantation in 131 consecutive recipients -
JD Cooper, GA Patterson, EP Trulock, WULT Group - The Journal of Thoracic and Cardiovascular Surgery, 1994 - AATS/WTSA
... Joel D. Cooper, MD , G. Alexander Patterson, MD , Elbert P. Trulock, MD (by invitation)
, the Washington University Lung Transplant Group St. Louis, Mo. ...

INTERNATIONAL GUIDELINES FOR THE SELECTION OF LUNG TRANSPLANT CANDIDATES. -
JR Maurer, AE Frost, M Estenne, T Higenbottam, AR … - Transplantation, 1998 - transplantjournal.com
... More than 6400 lung transplants have been performed since the first successful
operations in the early 1980s. ... Age limits: * Heart-lung transplants ~ 55 years. ...

… society for heart and lung transplantation: twentieth official adult lung and heart?lung transplant … -
EP Trulock, LB Edwards, DO Taylor, MM Boucek, PJ … - Journal of Heart and Lung Transplantation, 2003 - Elsevier
... The number of centers reporting heart?lung and lung transplants has gradually declined
since the mid-1990s (Figure 1). From a peak of 122 centers in 1996 ...

… for Heart and Lung Transplantation: Twenty-second Official Adult Lung and Heart-Lung Transplant … -
EP Trulock, LB Edwards, DO Taylor, MM Boucek, BM … - Journal of Heart and Lung Transplantation, 2005 - Elsevier
... Registry of the International Society for Heart and Lung Transplantation:
Twenty-second Official Adult Lung and Heart-Lung Transplant Report?2005. ...

Long-term health status and quality of life outcomes of lung transplant recipients -
CR Gross - Chest, 1995 - Am Coll Chest Phys
... of Chest Physicians. ARTICLES. Long-term health status and quality of life
outcomes of lung transplant recipients. CR Gross, K Savik ...

… of lung transplantation. A pilot study. University of Washington Medical Center Lung Transplant … -
SD Ramsey - Chest, 1995 - Am Coll Chest Phys
... We compared the costs and outcomes of the first 25 patients who received lung
transplants at the University of Washington with 24 patients currently on the ...

… survival of heart-lung and bilateral sequential lung transplant recipients with obliterative … -
VG Valentine, RC Robbins, GJ Berry, HR Patel, H … - J Heart Lung Transplant, 1996 - ncbi.nlm.nih.gov
J Heart Lung Transplant. ... Actuarial survival of heart-lung and bilateral sequential
lung transplant recipients with obliterative bronchiolitis. ...

The registry of the international society for heart and lung transplantation: sixteenth official … -
JD Hosenpud, LE Bennett, BM Keck, B Fiol, MM … - Journal of Heart and Lung Transplantation, 1999 - Elsevier
... The current report represents data on 48,541 cardiac transplants reported from 304
cardiac transplant programs, 2,510 heart-lung transplants reported from 124 ...

Cytomegalovirus Infection Is a Risk Factor for Invasive Aspergillosis in Lung Transplant Recipients -
RN Husni, SM Gordon, DL Longworth, A Arroliga, PC … - Clinical Infectious Diseases, 1998 - UChicago Press
... experience with invasive aspergillosis (IA) in lung transplant ... organ transplantation
including single lung transplants [abstract]. Chest 1993;104:155S. ...

The registry of the international society for heart and lung transplantation: eighteenth official … -
JD Hosenpud, LE Bennett, BM Keck, MM Boucek, RJ … - Journal of Heart and Lung Transplantation, 2001 - Elsevier
... DATA SET AND STATISTICAL METHODOLOGY The current report represents data on 57,818
car- diac transplants, 2,861 heart?lung transplants, 7,204 single lung ...

Source: Google Scholar

Groundwork Laid For Rejection-Free Lung Transplants In Humans
Lung transplants have been performed successfully for more than 20 years in humans but never before in mice -- until now. Surgeons at Washington University School of Medicine in St. Louis have developed the first mouse model of lung transplantation, and they're hoping it will help explain why the success of the procedure in humans lags far behind other solid organ transplants.

Ultimately, the mouse model could pave the way for developing new therapies to prevent lung transplant rejection -- a major problem that limits the long-term success of the procedure. The mouse model is described in the June issue of the American Journal of Transplantation.

Five years after lung transplant surgery, only about 45 percent of patients are still alive, according to the U.S. Organ and Procurement and Transplantation Network. This compares with five-year survival rates of about 70 percent for heart and liver transplants and about 80 percent for kidney transplants. About 1,000 lung transplants are performed each year in the United States.
"The high failure rate of lung transplants is a huge problem," says lung transplant surgeon Daniel Kreisel, M.D., Ph.D., an assistant professor of surgery and a lead investigator of the research. "Unlike other organs, lungs are constantly exposed to bacteria and viruses in the environment, and we think this exposure increases the risk of chronic rejection and the eventual failure of the organ. This is why the mouse model is so critical. It will allow us to understand the molecular mechanisms that control lung transplant rejection."

Lung transplants are the only treatment option for end-stage lung disease, including chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary fibrosis and certain congenital lung defects. Following a transplant, patients must take drugs for the rest of their lives that suppress the immune system and prevent it from attacking the new lung. This leaves them vulnerable to upper respiratory infections, which can quickly develop into pneumonia.

Kreisel and others suspect that these illnesses alter the immune response and increase inflammation, which eventually lead to chronic rejection. They note that mainstay immunosuppressive drugs simply are not effective at preventing chronic rejection for lung transplants, and they hope the mouse model will reveal why.

"The current hypothesis is that lung transplant rejection is linked to chronic inflammation from transient viral or bacterial infections, and this can be aggravated by the fact that transplant recipients are taking immunosuppressive drugs," Kreisel says.

Mouse models for heart, liver and kidney transplants have existed for years, but developing a similar model for lung transplantation has proved to be a real technical challenge. Mouse lungs measure less than an inch in length and the pulmonary vein and artery, which carry blood to and from the heart, are as thin as human hair.

Mikio Okazaki, M.D., a postdoctoral fellow, adapted the lung transplantation technique used in rats to the mice. He uses synthetic cuffs to join the donor vessels with those of the recipient. Okazaki has successfully performed several hundred lung transplants in the mice, and the team's analysis indicates the model simulates the same immune response that occurs in humans following lung transplantation.

Before Okazaki and his Washington University colleagues developed the mouse model, researchers had been studying lung transplantation using a nonphysiological mouse model in which a small section of trachea from one mouse was transplanted under the skin of another. Although it was simple to create, the model did not accurately mimic lung transplantation. "It was a very artificial model that had little to do with reality, Okazaki says. "We think the new model will be far better for studying the underlying immune mechanisms that lead to rejection."
The new mouse lung transplant model has an advantage over those in rats and larger animals because the genetics of mice are well documented and their genes are easier to manipulate. "With the mice, we can selectively delete genes to study their function in the transplanted lung or in the recipient, which we've not been able to do effectively in other animal models," says Andrew Gelman, Ph.D., an assistant professor of surgery, who is a lead investigator of this research. "By understanding the genes that control lung graft survival, researchers will be able to better guide the development of therapies to counteract chronic rejection."

The mouse model also will allow the researchers to investigate how other transplant-related complications affect the long-term success of the procedure. Many lung transplant patients experience gastric reflux, and doctors suspect this acid exposure damages the lining of the lung and further exposes the organ to pathogens. The mouse model will let researchers evaluate whether gastric reflux increases the risk of lung rejection.

Additionally, the time between surgery to harvest a donor lung and transplant it into a patient is widely suspected to affect its overall function after transplant surgery. The mouse model will help pinpoint the inflammation that underlies damage to the organ when it can't be transplanted quickly and may lead to ways to prevent such injury.

Based on mouse models of other solid organ transplants, researchers have learned that different groups of immune cells contribute to rejection in different organs. "Rejection of the lung differs from rejection of the heart in terms of the cells that participate in that rejection," says Alexander Sasha Krupnick, M.D., assistant professor of surgery. "Every organ is different. What we've learned about rejection of the heart in mice does not apply to lungs. So we are thrilled to finally have an acceptable mouse model of lung transplantation to help us discover ways to increase the success of these transplants in humans."

Okazaki M, Krupnick AS, Kornfeld CG, Lai JM, Ritter JH, Richardson SB, Huang HJ, Das NA, Patterson GA, Gelman AE, Kreisel, D. A mouse model of orthotopic vascularized aerated lung transplantation. American Journal of Transplantation. June 2007.

Grants from the National Heart, Lung and Blood Institute, the Thoracic Surgery Foundation for Research and Education, and Roche Pharmaceuticals supported this research.

Washington University School of Medicine's full-time and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked fourth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.

Source: Caroline Arbanas
Washington University School of Medicine
 
 
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