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Recent News and Articles on the Keywords: cancer + breast + brca  Related to the article below (Last Update: 8/5/2008)


RTE.ie
How MRI Scans Find Breast Cancers Like Christina Applegate's
U.S. News & World Report, DC -
When I first heard that actress Christina Applegate had breast cancer, I wondered how the 36-year-old's tumor was detected. Did she find the lump herself, ...
AssociatedPress
all 987 news articles »
Early screening is crucial to improving recovery rates for breast ...
Orlando Sentinel, FL -
"If a woman has a BRCA mutation" -- commonly found in Eastern European Jews -- "she has a 50 percent chance of having a whole new breast cancer in the ...
For the men who develop prostate cancer, early testing can improve ...
Orlando Sentinel, FL -
... risk: men whose father, uncles or brothers have had prostate cancer, and men whose mother had a form of breast cancer caused by a BRCA genetic mutation. ...
US Commercial Market Widens for Distribution of First Multi-Factor ...
Business Wire (press release), CA -
?The overwhelming majority of women at risk for breast cancer do NOT carry a single gene mutation such as BRCA1/2. Identifying those at risk, and those who ...

Oneindia
Family Poor Predictor of Breast Cancer
WebMD - Jul 22, 2008
A family history of breast cancer is not the same as breast cancer risk associated with the inherited mutations of BRCA1 or BRCA2 genes. ...
No Need For Gene Screens In Breast Cancer Families Science Daily (press release)
Early Breast Cancer Screening Called Superfluous Despite Family ... MedPage Today
Breast cancer in family ?not predictive? Irish Health
all 150 news articles »
Breast cancer treatment dilemma
Sydney Morning Herald, Australia - Jul 24, 2008
... BRCA1 and BRCA2 genes may fare better with particular forms of chemotherapy. For women with several close relatives who had already had breast cancer, ...
Genetic testing brings new hopes, hard choices
Boston Globe, United States - Aug 3, 2008
Currently, the best-known such decisions stem from knowledge of the BRCA genes that convey vastly higher risks of breast and ovarian cancer. ...

iAfrica.com
Facts of breast cancer
iAfrica.com, South Africa - Jul 29, 2008
Family history is a difficult relationship to interpret and the advent of potential testing for the so-called breast cancer genes, BRCA 1, BRCA 2 and BRCA 3 ...
Breast cancer tests 'will become costly'
The Age, Australia - Jul 14, 2008
... patents that allow it to carry out all testing for the most common breast and ovarian cancer genes, BRCA1 and BRCA2, in Australia and New Zealand. ...
Genes company in right to life battle The Australian
all 11 news articles »  GENE - PINK:GNTLF

PRESS TV
Breast cancer mortality increases with body mass index
Reuters - Jul 25, 2008
By Will Boggs, MD NEW YORK (Reuters Health) - A higher body mass index (BMI) is associated with lower survival rates in women with breast cancer, ...
BMI affects breast cancer survival rate PRESS TV
all 9 news articles »
Source: Google News

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 -
Y Miki, J Swensen, D Shattuck-Eidens, PA Futreal, … - Science, 1994 - sciencemag.org
... J. Biol. Chem. 279: 19643-19648 | Abstract ? | Full Text ? | PDF ? Incidence of
BRCA1 and BRCA2 Mutations in Young Korean Breast Cancer Patients. ...

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. -
DF Easton, D Ford, DT Bishop - American Journal of Human Genetics, 1995 - pubmedcentral.nih.gov
... paper we use data from families with evidence of linkage to BRCA1 to estimate the
age-specific risks of breast and ovarian cancer in BRCA1-mutation carriers ...

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations -
TR Rebbeck, HT Lynch, SL Neuhausen, SA Narod, L … - New England Journal of Medicine, 2002 - content.nejm.org
... Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers. ... Impact of
BRCA1/BRCA2 Counseling and Testing on Newly Diagnosed Breast Cancer Patients. ...

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families -
D Ford, DF Easton, M Stratton, S Narod, D Goldgar, … - The American Journal of Human Genetics, 1998 - UChicago Press
... The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage
and mutation analysis in 237 families, each with at least four cases of ...

Risk of cancer in BRCA 1-mutation carriers
D FORD, DF EASTON, DT BISHOP, SA NAROD, DE GOLDAR - Lancet(British edition), 1994 - cat.inist.fr
... of breast and ovarian cancer from the occurrence of second cancers in individuals
with breast cancer, and examined the risks of other cancers in BRCA 1 carriers ...

Decreased expression of BRCA 1 accelerates growth and is often present during sporadic breast cancer … -
ME Thompson, RA Jensen, PS Obermiller, DL Page, JT … - Nature Genetics, 1995 - nature.com
... | PubMed | ISI | ChemPort |; Friedman, LS et al.Confirmation of BRCA by analysis
of germline mutations linked to breast and ovarian cancer in ten ...

BRCA1 Mutations in Women Attending Clinics That Evaluate the Risk of Breast Cancer -
FJ Couch, ML DeShano, MA Blackwood, K Calzone, J … - New England Journal of Medicine, 1997 - content.nejm.org
... High incidence of skewed X chromosome inactivation in young patients with
familial non-BRCA1/BRCA2 breast cancer. J. Med. Genet. ...

… of BRCA 1 by analysis of germline mutations linked to breast and ovarian cancer in ten families -
LS Friedman, EA Ostermeyer, CI Szabo, P Dowd, ED … - Nature Genetics, 1994 - nature.com
... The search for BRCA1 and the cloning of 22 genes from chromosome 17q21. ... Inherited
breast cancer: Confirmation of linkage to BRCA2, possible linkage to ...

BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient … -
C Lerman, S Narod, K Schulman, C Hughes, A Gomez- … - JAMA, 1996 - Am Med Assoc
... ABSTRACT | FULL TEXT. Cost of Genetic Counseling and Testing for BRCA1 and
BRCA2 Breast Cancer Susceptibility Mutations Lawrence et al. ...

Gene-expression profiles in hereditary breast cancer -
I Hedenfalk, D Duggan, Y Chen, M Radmacher, M … - New England Journal of Medicine, 2001 - content.nejm.org
... A., Trent, J. (2003). Molecular classification of familial non-BRCA1/BRCA2
breast cancer. Proc. Natl. Acad. Sci. USA 100: 2532-2537 ...

Source: Google Scholar

Breast Cancer Survival Rates No Worse For Women With BRCA Mutations
Breast cancer patients who possess one of the so-called "breast cancer" or BRCA genetic mutations do not have a higher risk of dying than patients with no BRCA mutations, according to a detailed study by researchers at the Technion-Israel Institute of Technology and the University of Toronto. The findings are published in the July 12 issue of the New England Journal of Medicine.

Since some BRCA-related breast cancers occur earlier in life and can be resistant to common hormone treatments due to lack of hormone receptors in the tumor, researchers have wondered whether patients with the mutations might have a worse prognosis than others.
With the new study, "we can offer the reassurance that in spite of a bad profile of prognostic factors in carriers, their survival rate is actually at least as good as for noncarriers," said Technion researcher Dr. Gad Rennert.

The researchers looked at 1,545 Israeli women's survival rates 10 years after diagnosis, and found that the prognosis was similar among those with a mutation and those without. Ten years later, 33 percent of non-carriers, 33 percent BRCA1 carriers and 44 percent of BRCA2 carriers had died.

Dr. Rennert and Dr. Steven Narod, Director of the Familial Breast Cancer Research Unit of Women's College Research Institute, Toronto, and their colleagues say their findings could help women with BRCA mutations decide whether to pursue surgery or continue with vigilant screenings to lessen their chances of developing cancer.

The researchers took advantage of a unique set of medical records and tumor tissue samples from 1,545 Israeli women diagnosed with invasive breast cancer in the late 1980s. Among Jewish women of Ashkenazi descent in the study, two mutations of the BRCA1 gene and one BRCA2 mutation are especially prevalent.

However, since these women were diagnosed before the discovery of BRCA genes and received no special care as a result, the researchers were able to compare their survival rates directly to survival rates among patients without the mutations.

"The study can probably not be repeated with these advantages anywhere in the world, as Israel is the only place with such a high concentration of mutation carriers," Rennert noted.
Chemotherapy boosted the overall survival rates of patients with BRCA1 mutations, compared to survival rates among patients with no mutation. BRCA2 patients and patients with no mutation had similar survival rates, regardless of whether chemotherapy was part of their treatment.

"BRCA1 carriers seem in fact to be unusually sensitive to chemotherapy," said Narod. "These findings suggest that chemotherapy may benefit all women with a BRCA1 mutation, regardless of age or tumor size."

BRCA mutations can interfere with a cell's normal mechanisms for repairing damaged DNA, which may partially explain why chemotherapy had a different effect among BRCA1 patients, according to Rennert. Chemotherapy's attacks on cancer cells may be more effective if these cells already have problems repairing damage, he explained.

"We definitely need to further evaluate the role of specific chemotherapy agents in BRCA carriers to be able to better offer specific chemotherapies to patients," Rennert said.

The Technion-Israel Institute of Technology is Israel's leading science and technology university. Home to the country's winners of the Nobel Prize in science, it commands a worldwide reputation for its pioneering work in nanotechnology, computer science, biotechnology, water-resource management, materials engineering, aerospace and medicine. The majority of the founders and managers of Israel's high-tech companies are alumni. Based in New York City, the American Technion Society is the leading American organization supporting higher education in Israel, with 17 offices around the country.

American Technion Society
Technion-Israel Institute of Technology 55 East 59th St.
New York, NY 10022
United States
http://www.ats.org
 
 
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