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Recent News and Articles on the Keywords: new alzheimer's + alzheimers + criteria  Related to the article below (Last Update: 8/5/2008)

Exercise versus Alzheimer's
Chicago Tribune, United States -
The authors of that report hope to conduct a randomized clinical trial to see whether Alzheimer's patients who start a new exercise routine can actually ...
Surprising Things That Affect Memory Forbes
Maternal link to Alzheimer's suggested United Press International
all 5 news articles »
New chemical may help scan brain for signs of Alzheimer?s
Schenectady Gazette, NY -
By Kathy Ricketts (Contact) Shortly after Dr. Richard Holub started working with people with Alzheimer?s disease in 1985, magnetic resonance imaging became ...
Alzheimer drug slows cognitive decline
Irish Times, Ireland -
A NEW DRUG has slowed cognitive decline by up to 81 per cent in Alzheimer patients during early pharmaceutical trials, it has been announced. ...
Nymox Has Global Patent Rights For Statin Drugs For The Treatment ... Medical News Today (press release)
all 2 news articles »  NYMX

TheMedGuru
Alzheimer's disease researchers see progress on new drugs
EiTB, Spain - Aug 4, 2008
Despite some recent dramatic failures, Alzheimer's disease researchers say they have never been more encouraged by the wealth of promising new treatments ...
New drug halts Alzheimer's progression, scientists discover McKnight's Long Term Care News
Scots Create Drug to Halt Alzheimer's Pill is 'Biggest ... RedOrbit
More Doubts On New Alzheimer's Drug Forbes
Times Online - Dallas Morning News
all 48 news articles »  ELN - WYE

The Money Times
Elan Tanks As Buzz For New Alzheimer's Drug Dies
Forbes, NY - Jul 30, 2008
But at a big Alzheimer's meeting in Chicago, there is little buzz in the air over Wyeth and Elan's new drug bapineuzumab. ...
A Second Chance to Buy Wyeth? Barron's
Study Gets Mixed Results On Wyeth?s New Alzheimer?s Drug TopNews
Elan slumps 25 pct as Alzheimer's news disappoints International Herald Tribune
Reuters - Bloomberg
all 300 news articles »  ELN - PINK:ELNCF - WYE

Salem-News.Com
Alzheimer's patient reported missing
Statesman Journal, OR - 46 minutes ago
SALEM ? Authorities are searching for a reported missing man with Alzheimer's disease who last was seen at a northeast Salem assisted-living center Monday ...
Authorities seek Alzheimer's patient missing from Salem The Oregonian - OregonLive.com
Sheriff's Office Seeks Help in Locating Missing Alzheimer Patient‏ Salem-News.Com
all 3 news articles »

Telegraph.co.uk
Rosie Boycott: 'I wish the new Alzheimer's drug had come in time ...
Telegraph.co.uk, United Kingdom - Jul 30, 2008
But this new drug - called rember - could prove at least twice as effective in managing Alzheimer's disease as Aricept. The research team at the University ...
New Alzheimer's Drug Could Be Effective, Cheap, and Unprofitable Wired News
New Alzheimer's Drug Brings Hope Sky News
New Alzheimer's treatment slows mental decline, study shows Chicago Tribune
Belfast Telegraph - Telegraph.co.uk
all 630 news articles »
Program eases worry for caregivers of Alzheimer's patients
Las Cruces Sun-News, NM -
Agnes Vallejos, state director for the Alzheimer's Association New Mexico chapter, said often families don't realize the project exists, or, if they do, ...

ABC News
ABC News Medical Contributor
ABC News -
A new study from Kaiser Permanente, presented at last week's Alzheimer's Association International Conference on Alzheimer's Disease in Chicago, ...
Suven Life Sciences Presents Positive Preclinical Data for SUVN ... PharmaLive.com (press release)
all 3 news articles »  BOM:530239 - NSE:E:SUVEN.EQ
Alzheimer's drug trial at OHSU shows promise in some patients
Media Newswire (press release), NY -
A drug designed to remove amyloid plaques from the brain appears to help some patients with mild to moderate Alzheimer's disease, according to a clinical ...
Source: Google News

… of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and … -
HC Chui - Neurology, 1992 - AAN Enterprises
... The State of California Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC)
herein propose criteria for the diagnosis of ischemic vascular dementia ...

Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease -
R Mayeux, AM Saunders, S Shea, S Mirra, D Evans, AD … - New England Journal of Medicine, 1998 - content.nejm.org
... used in combination with clinical criteria, it improves ... RM, M.-XT), the Taub Alzheimer's
Disease Research ... College of Physicians and Surgeons, New York; Bryan ...

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices … -
G McKhann - Neurology, 1984 - AAN Enterprises
... P. Behl, and SE Black A New Visual Rating ... P Scheltens, and FRJ Verhey Do MCI criteria
in drug ... accurately identify subjects with predementia Alzheimer's disease ...

New Neuropathological Criteria for Alzheimer Disease -
BT Hyman - Archives of Neurology, 1998 - Am Med Assoc
... iterative process, and recently new recommendations have ... Research Institute of the
Alzheimer?s Association ... up- dating the neuropathological criteria for AD ...

Psychosis of Alzheimer's Disease and Related Dementias Diagnostic Criteria for a Distinct Syndrome -
DV Jeste, SI Finkel - ajgp, 2000 - Am Assoc Geria Psych
... implications. View this table: [in this window] [in a new window], TABLE 2.
Diagnostic criteria for psychosis of Alzheimer's disease (AD). One ...

… genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12 -
MA Pericak-Vance, MP Bass, LH Yamaoka, PC Gaskell, … - JAMA, 1997 - Am Med Assoc
... Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association
diagnostic criteria) and for ... region contains a new susceptibility gene ...

The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a … -
MC Tierney - Neurology, 1988 - AAN Enterprises
... Neuropathologic confirmation is required to validate the NINCDS-ADRDA Work Group
criteria for the clinical diagnosis of Alzheimer's disease (AD). ...

… of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal … -
AR Varma, JS Snowden, JJ Lloyd, PR Talbot, DMA … - British Medical Journal, 1999 - jnnp.bmj.com
... The validity of three clinical diagnostic criteria for Alzheimer's disease. ...
New York: Churchill Livingstone, 1996;9-41. 21. Snowden JS. ...

Development of scoring criteria for the clock drawing task in Alzheimer's disease. -
MF Mendez, T Ala, KL Underwood - J Am Geriatr Soc, 1992 - ncbi.nlm.nih.gov
Development of scoring criteria for the clock drawing task ... constructional apraxia,
in patients with Alzheimer's disease. ... reliability and validity of a new scale ...

Provisional Diagnostic Criteria for Depression of Alzheimer Disease Rationale and Background -
JT Olin, IR Katz, BS Meyers, LS Schneider, BD … - ajgp, 2002 - Am Assoc Geria Psych
... in this window] [in a new window], TABLE 2. Comparison of depression of Alzheimer
disease (AD ... for developing the provisional diagnostic criteria of depression of ...

Source: Google Scholar

New Diagnostic Criteria For Alzheimer's Disease

An international group of Alzheimer's disease (AD) experts have proposed new criteria for the reasearch diagnosis of the condition, as they argue the existing criteria are out of date due to unprecedented growth of scientific knowledge in the field. The proposal is put forward in a Position Paper published early Online and in the August edition of The Lancet Neurology.

AD is a neurodegenerative disease characterised by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioural changes. It is the most common form of dementia.
The existing criteria were published in 1984 by the National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders (NINCDS-ADRDA) working group.

Dr Bruno Dubois, Salpêtrière Hosptial, Paris, France, and colleagues, say: "[These existing criteria] are the prevailing diagnostic standards in research; however they have now fallen behind the unprecedented growth of scientific knowledge. Distinctive and reliable biomarkers of AD are now available through structural MRI, molecular neuroimaging with PET*, and cerebrospinal fluid analyses."

To meet the new criteria for probable AD, patients must show progressive memory loss over more than six months, plus at least one or more of the supportive biomarker criteria. These include: atrophy in a particular part of the brain shown by MRI, abnormal biomarker proteins in the cerebrospinal fluid, a specific pattern on PET of the brain, and a genetic mutation for AD within the immediate family. The authors say: "These new criteria are centred on a clinical core of early and significant episodic memory impairment…the timeliness of these criteria is highlighted by the many drugs in development that are directed at changing pathogenesis."

The researchers add that validation studies are required to advance the new criteria and optimise their sensitivity, specificity and accuracy.

They conclude: "When effective disease-modifying medications are available, the argument for such biologically based studies will be even more compelling.

"These proposed criteria move away from the traditional two-step approach of first identifying dementia according to degree of functional disability, and then specifying its cause. Rather, they aim to define the clinical, biochemical, structural, and metabolic presence of AD."
In an accompanying comment, Dr Norman Foster, Center for Alzheimer's Care, Department of Neurology, University of Utah, USA says: "We should seize this opportunity to reopen the discussion of Alzheimer's disease diagnosis. The time is right to use the advanced technology at our disposal to improve the early, accurate diagnosis of dementia and develop more effective treatments."

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