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Recent News and Articles on the Keywords: myeloid + leukemia + acute  Related to the article below (Last Update: 8/5/2008)


Bayside Leader
Brighton East girl shines through
Bayside Leader, Australia -
Chelsea, at home with mum Natalie Jacotine, is in remission after being diagnosed with acute myeloid leukemia. WITH her full head of hair, infectious smile ...
Cecil Sherman diagnosed with acute myeloid leukemia
Dallas Baptist Standard, TX - Jul 31, 2008
(ABP) -- Cooperative Baptist Fellowship pioneer Cecil Sherman has been diagnosed with acute myeloid leukemia. Sherman, 80, sought treatment options at MD ...
Author : The Leukemia & Lymphoma Society
Earthtimes (press release), UK -
Dr. Jordan's research is focused on myeloid leukemia stem cells, from which cancers derive and relapses evolve. Leukemia stem cells produce large numbers of ...

TopCancerNews.com
New clues into what causes mixed lineage leukemias and how might ...
TopCancerNews.com, TX - Jul 31, 2008
NS-SGM3 mice receiving the MLL-AF9-programmed cells all developed AML (acute myeloid leukemia) in five to seven weeks, even when most of the ...
Study Finds Methadone Can Destory Leukemia Cells With No Harm To ...
AHN -
... and her colleagues tested methadone in lymphoblastic leukemia T-cell lines and human myeloid leukemia cell lines in lab culture because this cancer also ...
Lorus Therapeutics Announces Allowance of New United States Patent ...
FOXBusiness - Jul 29, 2008
... in combination with high dose cytarabine (HiDAC) in patients less than 60 years of age with relapsed or refractory Acute Myeloid Leukemia (AML). ...LRP - OTC:CMTX
Three girls on Robert Gray soccer team contract serious illnesses
Longview Daily News, WA - Aug 3, 2008
And now they have acute lymphotic leukemia (Megan), acute myeloid leukemia (Hannah) and aplastic anemia ? sometimes a precursor to leukemia (Kaylynne). ...
Methadone Could Be Promising New Leukemia Treatment
RedOrbit, TX - Aug 3, 2008
Theirs is the first study to look at use of the agent in leukemia, specifically in lymphoblastic leukemia T-cell lines and human myeloid leukemia cell lines ...
ELACYT(TM) Clinical Update
ABN Newswire (press release), Australia - Jul 29, 2008
ELACYT is currently being tested in several clinical studies; Phase II in Acute Myeloid Leukemia (AML), Phase I in haematology in combination with ...OSL:CLAVIS
Sparing leukemia patients from unnecessary chemo
Reuters - Jul 29, 2008
In eight patients with a type of leukemia called acute myeloid leukemia (AML) undergoing a standard 7-day course of chemotherapy, Vanderhoek's team found ...
Source: Google News

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive … -
N Immunology, N Conferences, D Discovery - Nature Medicine, 1997 - palgrave-journals.com
... Human acute myeloid leukemia is organized as a hierarchy that originates from
a primitive hematopoietic cell. Dominique Bonnet & John E. Dick ...

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French- …
JM Bennett, D Catovsky, MT Daniel, G Flandrin, DA … - Ann Intern Med, 1985 - ncbi.nlm.nih.gov
1985 Oct;103(4):620-5. Proposed revised criteria for the classification of acute
myeloid leukemia. A report of the French-American-British Cooperative Group. ...

… the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia … -
BJ Druker, CL Sawyers, H Kantarjian, DJ Resta, SF … - New England Journal of Medicine, 2001 - content.nejm.org
... of Medicine -- Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in
the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia ...

Intensive Postremission Chemotherapy in Adults with Acute Myeloid Leukemia -
RJ Mayer, RB Davis, CA Schiffer, DT Berg, BL … - New England Journal of Medicine, 1994 - content.nejm.org
Original Article from The New England Journal of Medicine -- Intensive Postremission
Chemotherapy in Adults with Acute Myeloid Leukemia. ... Acute myeloid leukemia. ...

Acute Myeloid Leukemia -
B Lowenberg, JR Downing, A Burnett - New England Journal of Medicine, 1999 - content.nejm.org
Review Article from The New England Journal of Medicine -- Acute Myeloid Leukemia. ...
Acute Myeloid Leukemia and Acute Promyelocytic Leukemia. ...

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. -
M Nakao, S Yokota, T Iwai, H Kaneko, S Horiike, K … - Leukemia, 1912 - ncbi.nlm.nih.gov
Leukemia. 1996 Dec;10(12):1911-8. Internal tandem duplication of the flt3
gene found in acute myeloid leukemia. Nakao M, Yokota ...

[CITATION] Proposed revised criteria for the classification of acute myeloid leukemia
JM Bennett, D Catovsky, MT Daniel, G Flandrin, DAG … - Annals of Internal Medicine Volume 103, Number 4, 1985
-

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. -
H Kiyoi, T Naoe, Y Nakano, S Yokota, S Minami, S … - Blood, 1999 - ncbi.nlm.nih.gov
Blood. 1999 May 1;93(9):3074-80. Click here to read Prognostic implication
of FLT3 and N-RAS gene mutations in acute myeloid leukemia. ...

… Bone Marrow Transplantation in the Management of Acute Myeloid Leukemia in First Remission -
PA Cassileth, DP Harrington, FR Appelbaum, HM … - New England Journal of Medicine, 1998 - content.nejm.org
... Journal of Medicine -- Chemotherapy Compared with Autologous or Allogeneic Bone
Marrow Transplantation in the Management of Acute Myeloid Leukemia in First ...

… of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, … -
S Schnittger, C Schoch, M Dugas, W Kern, P Staib, … - Blood, 2002 - ncbi.nlm.nih.gov
... Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia:
correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and ...

Source: Google Scholar

Activity Of Gene Points To More Lethal Subtype Of Acute Myeloid Leukemia
A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy.

The gene, called ERG (for ETS-related gene), has also been linked to chronic leukemia and to breast and prostate cancer.

The findings apply to acute myeloid leukemia (AML) patients with leukemia cells that have normal-looking chromosomes, a feature that occurs in about half of AML patients.
Among these patients, those with leukemia cells showing high ERG activity are almost six times more likely to relapse or die within five years than are patients with low ERG expression following standard therapy.

The Cancer and Leukemia Group B study was initiated by researchers at the Ohio State University Comprehensive Cancer Center, and their findings were published online in the Journal of Clinical Oncology.

"Our study shows that high ERG activity predicts a poor prognosis in these patients, even when other molecular markers are taken into consideration," says first author Guido Marcucci, associate professor of internal medicine and an AML specialist at Ohio State's James Cancer Hospital and Solove Research Institute.

"The findings mean that these patients require a stem-cell transplant or other aggressive therapy, and that patients with low ERG activity can be treated using standard therapy."

The research confirms a 2005 study led by the same Ohio State researchers in a completely independent set of patients, Marcucci says.

"Both studies together further refine the molecular classification of AML in this group of patients and should help us improve treatment outcomes," says principal investigator Clara D. Bloomfield, professor of internal medicine, and an internationally recognized specialist in AML.

About 13,400 new cases of AML are expected this year, and a little more than half will have leukemia cells with normal-looking chromosomes. The rest will have chromosomes that show distinctive damage. In these patients, the type of damage helps doctors determine the best therapy and an individual's prognosis.
In 2005, Bloomfield, Marcucci and colleagues were the first to show that high ERG levels predicted a poor response to therapy in patients whose cancer cells have normal-looking chromosomes.

The present study was designed to verify that finding in a separate group of 76 AML patients under 60 years of age. It also took into consideration other genetic markers that signal whether the disease will respond well or poorly to standard therapy.

"We showed very similar results in this completely separate group of patients," Marcucci says. "After two years, only 29 percent of patients with high ERG were disease-free and alive versus 53 percent of patients with low ERG activity."



Funding from the National Cancer Institute and The Coleman Leukemia Research Foundation supported this research.

Source: Darrell E. Ward
Ohio State University
 
 
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