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Recent News and Articles on the Keywords: sarcoma + sarcomas + soft_tissue_sarcomas  Related to the article below (Last Update: 8/5/2008)

Immunotherapy Boosts Treatment of Kids' High-Risk Sarcomas
Washington Post, United States -
4 (HealthDay News) -- Immunotherapy shows promise in treating children with high-risk sarcomas, according to a US National Institute of Health pilot study. ...
8000 People Join The Team Sarcoma Initiative To Fight A Rare Cancer
Medical News Today (press release), UK -
From its humble beginnings in 2003, when seven people who called themselves "Team Sarcoma" biked 200 miles in Louisiana, the Team Sarcoma Initiative has ...
One Fifth Of British Adult Survivors Of Childhood Cancer Smoke ...
Science Daily (press release) -
The relatively high rate of smoking in survivors of Wilms tumor, Hodgkin lymphoma, and soft tissue sarcomas is concerning because previous research suggests ...
Immunotherapy In High-risk Pediatric Sarcomas Shows Promising Response
Science Daily (press release) - Aug 1, 2008
1, 2008) ? Based on a pilot study in children with sarcoma, researchers at the National Institutes of Health (NIH) believe that immunotherapy could prove ...
Concentrated Immunotherapy Feasible in High-Risk Pediatric Sarcoma
MedPage Today, NJ - Aug 1, 2008
1 -- Stimulating the immune system after chemotherapy shows promise in treating children with high-risk sarcoma, researchers said. ...
Three-year-old survives rare cancer
Monessen Valley Independent, PA - Aug 2, 2008
Isabella Carabin-Lindgren was diagnosed in March 2006 at 10 months old with Ewing's sarcoma in the brain. Ewing's sarcoma is a bone cancer that most often ...
Adjuvant Chemotherapy Confirmed Beneficial for Resectable Soft ...
Cancer Consultants, ID - Jul 24, 2008
1 Soft tissue sarcomas are a heterogeneous group of tumors with variable rates of recurrence after complete resection. The role of adjuvant chemotherapy and ...
Craig W. Philips Takes Helm at CTI
Trading Markets (press release), CA -
CTI is also developing brostallicin, another cancer drug for sarcoma currently in phase II/III trials. Brostallicin, a novel synthetic second- generation ...CTIC - OTC:CMTX
BRIEF: Sarcoma brief
Trading Markets (press release), CA - Jul 15, 2008
They will wear wristbands that proclaim "Sarcoma Knows No Borders" as they participate in more than 65 events in 14 countries and 22 states. ...
AIDS: Living with HIV
Fort Worth Star Telegram, TX - Aug 3, 2008
They frequently suffer debilitating weight loss and a type of cancer called Kaposi?s sarcoma (see below). AIDS wasting syndrome: Involuntary loss of 10 ...
Source: Google News

Kaposi's Sarcoma -
K Antman, Y Chang - New England Journal of Medicine, 2000 - content.nejm.org
... described five men with aggressive "idiopathic multiple pigmented sarcomas of the ...
investigators described four clinical variants of Kaposi's sarcoma that had ...

Epizootiology and distribution of transmissible sarcoma in Maryland softshell clams, Mya arenaria, … -
CA Farley, DL Plutschak, RF Scott - Environmental Health Perspectives, 1991 - JSTOR
... and occurrence of clam sarcomas have been demonstrated. For the present study, field
and laboratory examinations of prevalences of soft clam sarcoma and clam ...

[CITATION] The Classic: A System for the Surgical Staging of Musculoskeletal Sarcoma. -
WF Enneking, SS Spanier, MA Goodman - Clinical Orthopaedics and Related Research, 2003
... means of treating the majority of primary musculoskeletal sarcomas, and amputation ...
certain chemotherapeutic agents may have significant anti-sarcoma activity 2 ...

… and SSX, involved in the t (X; 18)(p 11. 2; q 11. 2) translocation found in human synovial sarcoma -
J Clark, PJ Rocques, AJ Crew, S Gill, J Shipley, … - Nature Genetics, 1994 - palgrave-journals.com
... BR, Wong, L. & Fisher, C. A consistent chromosomal translocation in synovial sarcomas. ...
change in human neoplasia: non random translocation In synovial sarcoma. ...

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma -
DM Brizel - Cancer Research, 1996 - AACR
... and treatment outcome in human soft tissue sarcoma. Twenty-two patients with
nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative ...

Fine-needle aspiration of synovial sarcoma: Criteria for diagnosis: Retrospective reexamination of …
M AKERMAN, W RYD, B SKYTTING - Diagnostic cytopathology, 2003 - cat.inist.fr
... An unequivocal diagnosis of sarcoma is possible when the yield is rich. ... for a correct
diagnosis, to avoid important pitfalls, such as other sarcomas with bland ...

SYT-SSX Gene Fusion as a Determinant of Morphology and Prognosis in Synovial Sarcoma -
A Kawai, J Woodruff, JH Healey, MF Brennan, CR … - New England Journal of Medicine, 1998 - content.nejm.org
... histologic subtype and the clinical behavior of synovial sarcoma. SYT?SSX fusion
transcripts are a defining diagnostic marker of synovial sarcomas and may ...

Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma -
PW Pisters, LB Harrison, DH Leung, JM Woodruff, ES … - Journal of Clinical Oncology, 1996 - jcojournal.org
... on local and systemic recurrence rates in patients with soft tissue sarcoma. ... further
therapy (no BRT) after complete resection of soft tissue sarcomas of the ...

… and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma -
AJ Crew, J Clark, C Fisher, S Gill, R Grimer, A … - EMBO J, 1995 - pubmedcentral.nih.gov
... X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two ... BR,
Wong L, Fisher C. A consistent chromosome translocation in synovial sarcoma. ...

… with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma -
D Lienard, P Ewalenko, JJ Delmotte, N Renard, FJ … - Journal of Clinical Oncology, 1992 - jco.ascopubs.org
... and After Hyperthermic Isolated Limb Perfusion of Soft Tissue Sarcoma and Melanoma ...
in Patients with Locally Advanced Soft Tissue Sarcomas: Treatment Response ...

Source: Google Scholar

Specialist Centres Should Deal With All Soft Tissue Sarcomas
Soft tissue sarcomas---rare tumours of the connective tissue---should be treated at the few centres which see most cases, in order to give patients the best chance of good outcomes, concludes an analysis of sarcoma management in Florida, published in the Annals of Surgery last month.

"STS [soft tissue sarcomas] are rare. This paucity leaves most health care institutions with low case volumes and outdated or inadequate resources, which impede the ability to offer optimal treatment of these rare and often complicated tumours," the authors explain.
Using an analysis of a large population-based state cancer registry in Florida, the Juan Gutierrez and colleagues tested the hypothesis that soft tissue sarcomas are better treated at institutions with higher volumes of cases. They used the Florida cancer data system, a prospective database of all cancer cases in the state of Florida since 1981, to identify all records of soft tissue sarcomas up to 2001. A total of 6259 cases were extracted and, after duplicates were removed, the researchers arrived at a total of 5564 unique cases. A final study sample of 4205 cases was created by excluding individuals who had non-surgical treatments.

Next, the researchers looked at the medical facilities where each person's treatment was done. A total of 256 institutions in Florida performed at least one resection of a soft tissue sarcoma between 1981 and 2001; these were grouped into percentile ranges by surgical procedure volume. Of 4673 surgical procedures recorded (including repeat procedures, which were excluded from the main analysis), 7 institutions performed 1504 cases (32.2%) and were classified as high volume centres. The remaining two thirds of institutions did 3169 cases (67.8% of the total) and were classed as low volume. "Our analysis of 20 years' surgical management of STS in Florida…[showed that] volumes in 213 facilities amounted to less than 1 case per year and less than 2 cases per year were managed at an additional 79 health care institutions," reported the authors.

Patients at high volume centres were generally younger, with a higher proportion of women, were more likely to have high-grade tumours and were more likely to receive radiation therapy and chemotherapy. When the authors looked at outcomes, they found that 30-day mortality rates were twice as high in low volume centres than in high volume institutions; there was a similar disparity with the 90-day mortality rate. Median 5-year and 10-year survival was significantly better for patients treated at high volume centres (40 months versus 37 months); however, survival of patients with extremity tumours was equal among the two groups of institutions. There was a slight selection bias in favour of the low volume centres because tumours managed at high volume places were higher grade and larger in size but despite this, higher volume centres achieved superior outcomes in patients with high grade lesions and those with tumours over 10 cm in size.
In an additional analysis, the researchers examined outcomes from treatment of extremity tumours alone to establish whether the volume of surgeries done at a centre affected the likelihood of patients keeping their limbs. A total of 1937 extremity tumours were analysed. At high volume centres, 90.6% of procedures for these tumours were limb sparing operations compared with 86.2% at low volume centres, suggesting that physicians at low-volume centres were more likely to resort to amputation to protect the patient's survival chances.

"This analysis reveals a direct correlation between hospital surgical volume and both short-term and long-term treatment outcomes for STS. While the observations reported here require confirmation with additional independent data sets they argue persuasively for exclusive referral of patients with STS to high volume specialised centres for optimal treatment, survival, and functional outcomes," conclude the authors.

Should soft tissue sarcomas be treated at high volume centres" An analysis of 4205 patients Juan Gutierrez, Eduardo Perez, Frederick Moffat, Alan Livingstone, Dido Fransceschi, and Leonidas Koniaris Annals of Surgery 2007; 245:952-58

Source: Corinne Hall
European School of Oncology
 
 
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