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Recent News and Articles on the Keywords: drugs + trial + glaucoma  Related to the article below (Last Update: 8/5/2008)

I-vation Implantable Drug Delivery System for The Eye Enters ...
Medgadget.com, CA -
... for delivery of drugs for conditions such as diabetic retinopathy and age-related macular degeneration, as well as anterior diseases such as glaucoma. ...SRDX
Othera files investigational new drug application for novel ...
OSN SuperSite (subscription), NJ - Aug 1, 2008
... Drug Administration to conduct a phase 1/2 safety and efficacy trial of an oculoselective beta-blocker for treating glaucoma and ocular hypertension, ...
Inspire Provides Update on Cystic Fibrosis Clinical Program
MarketWatch - Jul 29, 2008
Inspire has submitted a protocol amendment to the US Food and Drug Administration (FDA) and has begun implementation with clinical trial sites. ...ISPH
Othera files IND application for glaucoma drug
Pharmaceutical Business Review - Aug 1, 2008
By Staff Writer A Phase I-II safety and efficacy trial is planned for completion by the end of 2008. This study is a randomized, multi-center, ...
First half 2008 financial results: NicOx nears completion of phase ...
FOXBusiness - Jul 28, 2008
Abnormally raised IOP is one of the principal symptoms of glaucoma. On the primary endpoint at 28 days, PF-03187207 showed a 12% improvement over Xalatan(R) ...EPA:COX - OTC:CMTX
Long acting beta agonists first for COPD
6minutes, Australia -
by Michael Woodhead The first evidence that drug treatment can slow the decline in lung function in COPD has come from a major multinational study that ...
DEA agents raid Culver City medical marijuana dispensary
Los Angeles Times, CA - Jul 31, 2008
By Jia-Rui Chong, Los Angeles Times Staff Writer Federal drug enforcement agents raided a medical marijuana dispensary in the 13400 block of Washington ...
Hyperemia in Glaucoma Patients
Medscape (subscription) - Jul 25, 2008
Short- and long-term safety of glaucoma drugs. Expert Opin Drug Saf. 2002;1:181-194. Abstract Novack GD, O'Donnell MJ, Molloy DW. New glaucoma medications ...
EyeGate Pharma Initiates Landmark Clinical Study Employing the ...
MarketWatch - Jul 15, 2008
The pilot study was designed to assess the safety, tolerability and efficacy of EyeGate's first generation iontophoretic drug delivery device. In this trial ...
SemBioSys submits IND for safflower-produced insulin to US FDA
Canada NewsWire (press release), Canada - Jul 29, 2008
"The submission of the IND is a critical step toward the initiation of a Phase I/II clinical trial with our recombinant human insulin produced from ...
Source: Google News

The uniocular drug trial and second-eye response to glaucoma medications -
T Realini, RD Fechtner, SP Atreides, S Gollance - Ophthalmology, 2004 - Elsevier
... Published by Elsevier Science Inc. Original article. The uniocular drug
trial and second-eye response to glaucoma medications *1. ...

… patients with ocular hypertension and glaucoma: a six-month masked, multicenter trial in the United … -
CB Camras - Ophthalmology, 1996 - ncbi.nlm.nih.gov
Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma:
a six-month masked, multicenter trial in the United States. ...

… glaucoma or ocular hypertension: a post hoc analysis of an open-label community trial. Glaucoma … -
DA Lee, J Gornbein, C Abrams - J Ocul Pharmacol Ther, 2000 - ncbi.nlm.nih.gov
... During the 2-month trial, data were collected ... parameters were evaluated, including
glaucoma medications (visit 1 ... grouped according to specific drug regimen, and ...

… Topical Ocular Hypotensive Medication Delays or Prevents the Onset of Primary Open-Angle Glaucoma -
MA Kass, DK Heuer, EJ Higginbotham, CA Johnson, JL … - Archives of Ophthalmology, 2002 - Am Med Assoc
... Combination drugs are counted twice. ... compared with the other participants in the
trial (hazard ratio ... Primary open-angle glaucoma developed in 14 (6.9%) of 203 ...

… tartrate 0.2% and timolol 0.5% given twice daily in patients with glaucoma or ocular hypertension. … -
RP LeBlanc - Ophthalmology, 1998 - ncbi.nlm.nih.gov
... parallel-group, active-controlled, multicenter clinical trial of 12 ... Four hundred
eighty-three patients with glaucoma or ocular ... Both drugs were well-tolerated. ...

Treatment for glaucoma: adherence by the elderly. -
JH Gurwitz, RJ Glynn, M Monane, DE Everitt, D … - American Journal of Public Health, 1993 - pubmedcentral.nih.gov
... therapy versus no treatment in the management of glaucoma suspects. ... with ocular
hypertension: a five-year, randomized, double-masked, clinical trial. ... Drugs. ...

… of Intraocular Pressure and Glaucoma Progression: Results From the Early Manifest Glaucoma Trial -
A Heijl, MC Leske, B Bengtsson, L Hyman, B … - Archives of Ophthalmology, 2002 - archopht.highwire.org
... Progression Results From the Early Manifest Glaucoma Trial. Anders ... The
Early Manifest Glaucoma Trial (EMGT) began in 1992. It is ...
-

… and information leaflets on adherence to drug treatment in primary care: randomised controlled trial -
R Peveler, C George, AL Kinmonth, M Campbell, C … - BMJ, 1999 - pubmedcentral.nih.gov
... a contraindication (allergy, heart disease, glaucoma, or pregnancy ... 6 and 12 weeks,
and the trial was analysed ... investigated time to stopping drugs using survival ...

… vs Drug Treatment for Urge Urinary Incontinence in Older Women A Randomized Controlled Trial -
KL Burgio, JL Locher, PS Goode, JM Hardin, BJ … - JAMA, 1998 - Am Med Assoc
... past the introitus, narrow-angle glaucoma, unstable angina ... study was a randomized
placebo-controlled trial. ... assigned to behavioral treatment, drug treatment, or ...

… versus trabeculectomy in white patients with open-angle glaucoma A randomized clinical trial -
CP Jonescu-Cuypers, PC Jacobi, W Konen, GK … - Ophthalmology, 2001 - Elsevier
... Randomized controlled trial. ... as is usual in our setting after performing glaucoma
surgery ... depending on the application of antiglaucomatous drugs and performance ...

Source: Google Scholar

Early trial suggests promise for glaucoma drug

Last Updated: 2007-07-18 13:44:37 -0400 (Reuters Health)

CHICAGO - An experimental drug to treat glaucoma appears promising based upon the results of early-stage trials sponsored by the drug's maker Alcon Inc., analysts said on Wednesday.

The results of the phase II study of anecortave acetate in glaucoma were presented at the World Glaucoma Congress in Singapore.

Glaucoma refers to eye diseases that affect the optic nerve and cause vision loss. Most of these diseases cause high pressure inside the eye, called intraocular pressure (IOP). Elevated IOP is the most important risk factor for the development of glaucoma.

Despite a high dropout rate in the trial, anecortave acetate "showed strong potential for sustained reduction of IOP," Mike Weinstein, an analyst with JP Morgan, wrote in a research note.

While statistical significance was not reached in the groups that received lower doses of the drug, significance was achieved in the group that received the drug at the highest dose.

Alcon, an eye-care products maker, said an additional larger study would be needed for approval and estimated it would file a new drug application with U.S. regulators in 2009 versus its earlier estimate of 2008.

(Reporting by Debra Sherman, editing by Jeffrey Benkoe)

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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