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Recent News and Articles on the Keywords: duchenne + prolong + web  Related to the article below (Last Update: 8/5/2008)

Locals raise ?180000 to help save boys' lives
Irish Independent, Ireland -
... to help prolong the lives of brothers Tony (7) and Bobby (2) Lafferty and Liam Mooney (6). The boys are among 150 Irish boys who suffer from Duchenne ...
Navigating life after death
Brisbane Times, Australia - Jul 21, 2008
We observed the Duchenne smile, which does not reach eye muscles. In bereavement we are no longer who we were. Sadness gives us room to turn inwards and ...
Source: Google News

Prednisone treatment in Duchenne muscular dystrophy. Long-term benefit -
S DeSilva, DB Drachman, D Mellits, RW Kuncl - Archives of Neurology, 1987 - Am Med Assoc
... Web browser does not support basic Web standards. ... in the treatment of Duchenne muscular
dystrophy ... that ambulation was significantly prolonged, by approximately ...

Symptomatic nephrolithiasis in prolonged survivors of Duchenne muscular dystrophy.
Y Shumyatcher, TA Shah, GH Noritz, BH Brouhard, JP … - Neuromuscul Disord, 2008 - ncbi.nlm.nih.gov
... work well with NCBI's Web applications. More information here... ... Symptomatic
nephrolithiasis in prolonged survivors of Duchenne muscular dystrophy. ...

Rapacuronium Administration to Two Children with Duchenne's Muscular Dystrophy -
GA Frankowski, JO Johnson, JD Tobias - Anesthesia & Analgesia, 2000 - IARS
... Search for citing articles in: ISI Web of Science ... rapacuronium in two patients with
DMD is prolonged. ... during anaesthesia in patients with Duchenne?s muscular ...

Diurnal ventilation via mouthpiece: survival in end-stage Duchenne patients -
M Toussaint, M Steens, G Wasteels, P Soudon - European Respiratory Journal, 2006 - ersj.org.uk
... including 95% confidence interval) of daytime ventilation via mouthpiece in Duchenne
patients ... for 5 yrs with NIPPV 10, giving them the chance to prolong life to ...

Patient information: Overview of muscular dystrophies -
M FUNCTION, DM DYSTROPHY, BM DYSTROPHY, EDM … - patients.uptodate.com
... DUCHENNE MUSCULAR DYSTROPHY ? Duchenne muscular dystrophy (DMD) is ... joint to its normal
position and prolong walking with ... every four months on our web site (www ...

Postoperative use of a cough-assist device in avoiding prolonged intubation -
WA Marchant, R Fox - British Journal of Anaesthesia, 2002 - British Jrnl Anaesthesia
... retention and ventilatory failure, which may lead to prolonged intensive care ... with
severe neuromuscular disorders, such as SMA and Duchenne muscular dystrophy ...

Long-term Ventilation for Patients With Duchenne Muscular Dystrophy* Physicians' Beliefs and … -
B Gibson - Chest, 2001 - Am Coll Chest Phys
... Search for citing articles in: ISI Web of Science (8 ... 2 In the past, individuals with
Duchenne muscular dystrophy ... ventilation has been shown to prolong the lives ...

… Plasmid-Mediated Dystrophin Expression in the mdx Mouse Model for Duchenne Muscular Dystrophy by a … -
C Bertoni, S Jarrahian, TM Wheeler, Y Li, EC … - Molecular Therapy, 2005 - nature.com
... Duchenne muscular dystrophy is caused by lack of dystrophin expression in ... of
extrachromosomal vectors to sustain gene expression for prolonged periods of time ...

Intermittent Prednisone Therapy in Duchenne Muscular Dystrophy A Randomized Controlled Trial -
EAC Beenakker, JM Fock, MJ Van Tol, NM Maurits, HM … - Archives of Neurology, 2005 - Am Med Assoc
... Web browser does not support basic Web standards. ... Background Prednisone treatment
is used to prolong ambulation in patients with Duchenne muscular dystrophy ...

A new age for childhood diseases: Duchenne muscular dystrophy -
T METULES - RN: National Magazine for Nursing, 2002 - mediwire.sma.org
President's Welcome. Mission/Vision. Leadership. Special Service Awards. Press Releases.
FAQ. Southern Medical Journal. CME Calendar. CME Online Library. ...

Source: Google Scholar
 

Steroids prolong walking in Duchenne MS

Last Updated: 2007-05-09 15:32:28 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Boys with Duchenne muscular dystrophy, the most common type of muscular dystrophy, who are treated with long-term steroid therapy are able to walk on their own for several more years than boys not treated with steroids, according to findings published in the May issue of Neurology. However, this benefit comes at the cost of more fractures.

Duchenne muscular dystrophy "is rapidly progressive, with most boys losing the ability to walk between ages 9 and 11," write Dr. J. T. Kissel and colleagues from Ohio State University, Columbus.

In their study, the researchers examined the effects off long-term daily corticosteroid treatment on a number of orthopedic outcomes in boys with Duchenne muscular dystrophy. Of 159 charts that were reviewed, 143 were included in the group (16 patients with Becker dystrophy were excluded.)

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Seventy-five patients (52.4 percent) had been treated with daily steroids for at least 1 year (average duration 8 years). Sixty-eight boys (47.6 percent) had never received steroid treatment or they had been treated for less than 6 months.

Independent walking stopped after an average age of 9.21 years in the untreated group, compared with 12.52 years in the steroid-treated group, a statistically significant difference.

The investigators found that 91 percent of untreated boys and 31 percent of treated boys had scoliosis (curvature of the spine), and 29 percent and 15 percent of the untreated and treated subjects, respectively, had undergone scoliosis surgery. The mean degree of scoliosis was 33.15 degrees for the untreated group and 11.58 degrees for the treated group.

However, 38.7 percent of steroid-treated patients had long-bone fractures, compared with 26.5 percent of untreated patients. No vertebral compression fractures were observed in the untreated group, whereas vertebral compression fractures occurred in 32 percent of the treated group.

"Because of the orthopedic implications of steroid therapy in this population, aggressive prophylactic measures are indicated as soon is therapy as initiated," Kissel's team stresses. Whether bisphosphonate drugs to strengthen bones, such as Actonel, have a role in preventing osteoporosis in this setting "remains to be determined."

SOURCE: Neurology May 8, 2007.

Copyright © 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 
 
 
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