Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: new + hamilton + college  Related to the article below (Last Update: 8/5/2008)

Opportunity Too Good For Pendergast To Pass Up
Hartford Courant, United States -
As a former head coach at Cornell (2001-03) and Hamilton College (2000), Pendergast brings so much to the role. "Because I've been a head coach, ...
Hamilton wins, advances to Middle Atlantic semifinals
The Times of Trenton - NJ.com, NJ -
The winners of that contest and the first semifinal between College Point (Metro New York) and State College, Pa., will meet tomorrow night for the regional ...
More students push dorms to limits
Utica Observer Dispatch, NY -
Hamilton College officials could not be reached Monday. SUNYIT and Herkimer County Community College also have programs that gather landlord information and ...
College postcards Observer-Dispatch Utica Observer Dispatch
all 2 news articles »
EIU basketball gets new hope from recruits
Journal Gazette and Times-Courier, IL -
... last year as a junior college sophomore; Dewayne Wright Jr., who averaged 18.4 points for Highland Community College in Kansas; and Will Hamilton, ...
Colston nursing new knee injury
Jackson Clarion Ledger, MS -
Colston had suffered and recovered from a sore left knee that was drained in the early days of New Orleans training camp at Millsaps College. ...
State College falls in New Jersey
Centre Daily Times, PA - Aug 2, 2008
WASHINGTON TOWNSHIP, NJ ? Hamilton, NJ, gained an early lead and later added seven runs in the sixth inning to seal an 18-7 victory over State College in ...
Falling short Centre Daily Times
all 2 news articles »
New nurses who have shown special qualities are honoured
ChronicleLive, UK -
The awards were a bequest by South Shields-born George Yeoman Heath ? a surgeon, teacher, president of the College of Medicine in Newcastle and the first ...
Saints add 2 defensive tackles
Boston Herald, United States -
The new linemen are Tim McGill and James Reed. To make room on the 80-man roster, the Saints waived receiver Curtis Hamilton and defensive end Marquies Gunn ...

Waikato Times
From Chile to wet
Waikato Times, New Zealand -
If you think there's been an uncommon amount of rain lately, spare a thought for Hamilton visitor Rafael Perea. Rain is an alien phenomenon for the ...
Crisis is here for ob-gyn doctors - and patients
Lower Hudson Journal news, NY -
A 2006 survey from the American College of Obstetricians and Gynecologists found that 66 percent of New York State ob-gyns reported having made at least one ...
Source: Google News

[CITATION] Evaluation as illumination: A new approach to the study of innovatory programs
M Parlett, D Hamilton - Evaluation Studies Review Annual, 1976 - Sage Pubns

[BOOK] Handbook of Social Support and the Family
GR Pierce, BR Sarason, IG Sarason - 1996 - books.google.com
... Handbook of Social Support and the Family Edited by Gregory R. Pierce Hamilton College
Clinton, New York Barbara R. Sarason University of Washington Seattle ...

New upper limits on the local metagalactic ionizing radiation density -
SN Vogel, R Weymann, M Rauch, T Hamilton - The Astrophysical Journal, 1995 - adsabs.harvard.edu
Title: New upper limits on the local metagalactic ionizing ... Stuart N.; Weymann, Ray;
Rauch, Michael; Hamilton, Tom. ... AA(University of Maryland, College Park, MD ...

Phase I Study of Adenoviral Delivery of the HSV-tk Gene and Ganciclovir Administration in Patients … -
… PR Wyde, JC Goodman, WJ Hamilton, A Rojas-Martinez … - Molecular Therapy, 2000 - nature.com
... J. Clay Goodman *,**, Winifred J. Hamilton * , Augusto Rojas ... Cell and Gene Therapy,
Baylor College of Medicine ... Sinai School of Medicine, New York, New ...

[BOOK] The New Russians
H Smith - 1990 - Random House
-

[BOOK] Apprenticeship for adulthood: preparing youth for the future -
SF Hamilton - 1990 - tcrecord.org
... Worse, as many no college youth see little benefit ... Hamilton suggests that this haphazard
system seems to ... participation rates were bringing many new entrants to ...

New prostheses for use in bypass grafts with special emphasis on polyurethanes. -
A Tiwari, H Salacinski, AM Seifalian, G Hamilton - Cardiovasc Surg, 2002 - ncbi.nlm.nih.gov
Click here to read New prostheses for use in bypass ... Tiwari A, Salacinski H, Seifalian
AM, Hamilton G. Tissue ... and Royal Free & University College Medical School ...

The Influence of Fashion Magazines on the Body Image Satisfaction of College Women: An Exploratory … -
SL Turner, H Hamilton, M Jacobs, LM Angood, DH … - Adolescence, 1997 - questia.com
... by Sherry L. Turner , Heather Hamilton , Meija Jacobs ... of body image satisfaction
among college women ... an introductory psychology course at a New England women's ...

A NEW PROCEDURE FOR THE DETERMINATION OF THE FINE STRUCTURE OF POLYSACCHARIDES
M Abdel-Akher, JK Hamilton, R Montgomery, F Smith - Journal of the American Chemical Society, 1952 - pubs.acs.org
... By application of the new procedure reported herein to ... AKHER CPIVERSITY OF MIUTESOTA
T R HAMILTON ST PAEL ... OF PHYSICS THE PEUNSYLVANIA STATE COLLEGE STATE COLLEGE ...

[BOOK] New Venture Creation: Entrepreneurship for the 21st Century with PowerWeb and New Business Mentor CD
JA Timmons, S Spinelli - 2003 - McGraw-Hill/Irwin
-

Source: Google Scholar
 

Hamilton College Researchers Discover New Molecules with the Potential to Treat Breast Cancer

Article published in Highly Cited Journal of the American Chemical Society

Contact: Holly Foster
Phone: (315) 859-4068
May 4, 2007

Hamilton College researchers have identified molecules that have been shown to be effective in the fight against breast cancer.

The Hamilton researchers used state-of-the-art computational techniques in a novel way to design molecules that they predicted would be effective lead compounds for breast cancer research. Scientists from the Albany Medical College subsequently synthesized the predicted molecules and showed that they were indeed potential anti-breast cancer compounds in animal systems.

A paper detailing the research, “Computational Design and Experimental Discovery of an Anti-estrogenic Peptide Derived from Alpha-Fetoprotein,” will be published in the May 16 issue of the Journal of American Chemical Society.

Article continues below and (thank you)
 

Figure of the an active 8 amino acid peptide. Solvent accessible surface is shown.

Figure of the an active 8 amino acid peptide. Solvent accessible surface is shown.
 
Winslow Professor of Chemistry George Shields and co-director of the Center for Molecular Design Karl Kirschner led the Hamilton research team with undergraduate students Katrina Lexa ‘05, Amanda Salisburg ‘08, Katherine Alser ‘09. The Albany team consisted of Leroy Joseph, Thomas Andersen, James Bennett, and Herbert Jacobsen of Albany Medical College.

Breast cancer is the most common cancer among women and tamoxifen is the preferred drug for estrogen receptor-positive breast cancer treatment. Many of these cancers are intrinsically resistant to tamoxifen or acquire resistance during treatment. Consequently, there is an ongoing need for breast cancer drugs that have different molecular targets.

Previous work by the Albany Medical College researchers had shown that 8-mer and cyclic 9-mer peptides inhibit breast cancer in mouse and rat models, interacting with an unsolved receptor, while peptides smaller than eight amino acids did not.

The Hamilton researchers used advanced computational methods to predict the structure and dynamics of active peptides, leading to discovery of smaller peptides with full biological activity. The results were used to identify smaller peptides with the three dimensional structure of the larger peptides. These peptides were synthesized and shown to inhibit estrogen-dependent cell growth in a mouse uterine growth assay, a test showing reliable correlation with human breast cancer inhibition.

This work was funded by the National Institutes of Health, the New York State Breast Cancer Research and Education fund, the Department of Defense's Breast Cancer program, and the National Science Foundation.

Founded in 1879, the Journal of the American Chemical Society is the flagship journal of the American Chemical Society and the premier medium for the worldwide publication of fundamental research in all areas of the chemical sciences. It is the most highly cited chemistry journal.

The results reported in the published article were first presented by Professor Shields at the 2006 International Symposium on Theory and Computations in Molecular and Materials Sciences, Biology and Pharmacology, on February 26, 2006, St. Simon’s Island, Ga.


The project was sponsored in part by the Department of the Army under contract # W81XWH-05-1-0441. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014 is the awarding and administering acquisition office. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.

It was supported by the New York State Breast Cancer Research and Education Fund through Department of Health Contract # C017922. Opinions expressed are solely those of the author and do not necessarily reflect those of the Health Research Science Board, the New York Department of Health, of the State of New York.

This material is based upon work supported by the National Science Foundation under Grant No. (CHE-0457275). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

Part of the Federal support came from the National Institutes of Health/National Cancer Institute. Federal money represents $475,870 or 82% of total project costs; non-federal funds equal $100,000 or 18% of total project costs.
 
Google
Web www.iconocast.com
 
 
Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services.

 

Iconocast Home Page

 © 2002-2006

Keywords:

Contact Iconocast